反复呼吸道感染患儿维生素A、D、K水平与中医证型相关性分析

Correlation of the levels of vitamins A,D,and K with TCM syndrome types in children with recurrent respiratory tract infection

目的:分析反复呼吸道感染(RRTI)患儿维生素A、D、K水平特点,并探讨其与中医证型的相关性,为RRTI的防治提供新的思路。方法:选取228例3~7岁RRTI患儿为研究对象,收集其临床资料并进行中医辨证分型,并纳入74例同年龄段的正常儿童作为对照组。比较2组儿童的维生素A、D、K水平;并采用Logistic回归分析探讨RRTI组儿童维生素A、D、K水平与中医证型的关系。结果:RRTI患儿的维生素A、D水平低于正常组儿童(P<0.01);维生素A水平与肺脾气虚型RRTI、维生素D水平与脾肾两虚型RRTI、维生素K水平与胃肠积热型RRTI的发病率呈负相关。结论:RRTI患儿的维生素A、D水平偏低;且维生素A、D、K水平与RRTI中的某些中医证型存在相关性。

Objective:To investigate the characteristics of the levels of vitamins A,D,and K in children with recurrent respiratory tract infection(RRTI)and their correlation with TCM syndrome types,and to provide new ideas for the prevention and treatment of RRTI.Methods:A total of 228 children with RRTI,aged 3-7 years,were enrolled as subjects,and their clinical data were collected for TCM syndrome differentiation;74 normal children of the same age group were enrolled as control group.The levels of vitamins A,D,and K were compared between the two groups,and the logistic regression analysis was used to investigate the association between the levels of vitamins A,D,and K and TCM syndrome types.Results:The RRTI group had significantly lower levels of vitamins A and D than the control group(P<0.01).Vitamin A level was negatively correlated with the incidence rate of RRTI with Qi deficiency of lung and spleen,vitamin D level was negatively correlated with the incidence rate of RRTI with deficiencyof spleen and kidney,and vitamin K level was negatively correlated with the incidence rate of RRTI withaccumulated heat in stomach and intestine. Conclusion: There are relatively low levels of vitamins A and D in childrenwith RRTI,and the levels of vitamins A,D,and K are correlated with certain TCM syndrome types of RRTI.