沙美特罗替卡松联合噻托溴铵对COPD急性加重期患者炎性反应及肺功能的影响

Impact of Salmeterol Fluticasone Combined with Tiotropium Bromide on Inflammatory Response and Lung Function of Patients with Acute Exacerbation of COPD

目的探讨沙美特罗替卡松联合噻托溴铵对COPD急性加重期(AECOPD)患者炎性反应及肺功能的影响。方法86例AECOPD患者随机分为两组。在常规治疗基础上,对照组给予噻托溴铵粉雾剂吸入治疗,观察组采用噻托溴铵粉雾剂吸入联合沙美特罗替卡松气雾剂治疗。比较两组的炎性因子、肺功能以及不良反应。结果治疗后,观察组的IL-8、TNF-α及hs-CRP水平均低于对照组,FEV_(1)、PEF、FVC均高于对照组(P<0.05)。两组治疗期间的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论沙美特罗替卡松联合噻托溴铵治疗AECOPD可显著减轻患者的炎性反应,改善患者的肺功能,且安全性较高。

Objective To explore the impact of salmeterol fluticasone combined with tiotropium bromide on inflammatory response and lung function of patients with acute exacerbation of COPD(AECOPD).Methods 86 patients with AECOPD were randomly divided into two groups.On the basis of routine treatment,the control group was treated with tiotropium bromide powder inhalation,while the observation group was treated with tiotropium bromide powder inhalation combined with salmeterol fluticasone aerosol.The inflammatory factors,lung function and adverse reactions were compared between the two groups.Results After treatment,the levels of IL-8,TNF-α and hs-CRP in the observation group were lower than those in the control group,and FEV_1,PEF and FVC were higher than those in the control group(P <0.05).No significant difference was found in the total incidence of adverse reactions during treatment between the two groups(P>0.05).Conclusions Salmeterol fluticasone combined with tiotropium bromide in the treatment of AECOPD can significantly reduce the inflammatory response and improve the lung function of patients,with higher safety.