大剂量连续性肾脏替代疗法对急诊脓毒症患者炎性因子水平及微循环的影响

Impact of High-Dose Continuous Renal Replacement Therapy on Inflammatory Factor Levels and Microcirculation of Patients with Emergency Sepsis

目的探讨大剂量连续性肾脏替代疗法在急诊脓毒症患者治疗中的应用效果。方法62例急诊脓毒症患者随机分为两组。在常规治疗基础上,对照组采用常规剂量连续性肾脏替代疗法治疗,观察组采用大剂量连续性肾脏替代疗法治疗。比较两组的炎性因子水平、微循环指标。结果治疗48 h后,两组的IL-6、TNF-α水平均较治疗前降低,且观察组的IL-6、TNF-α水平均低于对照组(P<0.05)。治疗48 h后,两组的MFI、PPV均较治疗前升高,且观察组的MFI、PPV均高于对照组(P<0.05)。结论大剂量连续性肾脏替代疗法治疗急诊脓毒症患者可显著降低其炎性因子水平,改善其微循环。

Objective To explore the application effect of high-dose continuous renal replacement therapy in the treatment of patients with emergency sepsis.Methods 62 patients with emergency sepsis were randomly divided into two groups.On the basis of conventional treatment,the control group was treated with conventional dose continuous renal replacement therapy,and the observation group was treated with high-dose continuous renal replacement therapy.The levels of inflammatory factors and the microcirculation indicators were compared between the two groups.Results After 48 hours of treatment,the levels of IL-6 and TNF-α in the two groups were lower than those before treatment,and the levels of IL-6 and TNF-α in the observation group were lower than those in the control group(P <0.05).After 48 hours of treatment,MFI and PPV in the two groups were higher than those before treatment,and MFI and PPV in the observation group were higher than those in the control group(P <0.05).Conclusions High-dose continuous renal replacement therapy in the treatment of patients with emergency sepsis can significantly reduce the levels of inflammatory factors and improve their microcirculation.