奥美拉唑联合奥曲肽治疗肝硬化食管胃底静脉曲张破裂出血的临床效果

Clinical Effect of Omeprazole Combined with Octreotide in the Treatment of Esophageal-Gastric Variceal Bleeding Caused by Cirrhosis

目的 探讨奥美拉唑联合奥曲肽治疗肝硬化食管胃底静脉曲张破裂出血(EGVB)的临床效果。方法 100例肝硬化EGVB患者随机分为两组。在常规治疗基础上,对照组采用奥曲肽治疗,研究组采用奥美拉唑联合奥曲肽治疗。比较两组的治疗效果、临床指标以及不良反应。结果 治疗后,研究组的总有效率高于对照组,输血量、再出血率均低于对照组,止血时间短于对照组,24 h止血率高于对照组(P <0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论 奥美拉唑联合奥曲肽治疗肝硬化EGVB的效果确切,可有效止血且安全性较高。

Objective To explore the clinical effect of omeprazole combined with octreotide in the treatment of esophageal-gastric variceal bleeding(EGVB) caused by cirrhosis.Methods 100 patients with EGVB caused by cirrhosis were randomly divided into two groups.On the basis of routine therapy,the control group was treated with octreotide,and the study group was treated with omeprazole combined with octreotide.The treatment effect,clinical indicators and adverse reactions were compared between the two groups.Results After treatment,the total effective rate of the study group was higher than that of the control group,the blood transfusion volume and rebleeding rate were lower than those of the control group,the hemostasis time was shorter than that of the control group,and the hemostasis rate within24 h was higher than that of the control group(P <0.05).No significant difference was found in the total incidence of adverse reactions between the two groups(P >0.05).Conclusions Omeprazole combined with octreotide in the treatment of EGVB caused by cirrhosis has exact effect,which can effectively stop bleeding and has high safety.