从肠道菌群-胆汁酸轴探讨高血压“土虚木郁”病机的生物学内涵

Exploration on the Biological Implications of“Earth Deficiency and Wood Depression”Pathogenesis of Hypertension from Intestinal Flora-bile Acid Axis

肠道菌群与胆汁酸间存在双向关系,肠道菌群-胆汁酸轴代谢失衡与高血压密切相关。本文基于中医经典文献梳理及临床实践发现,“土虚”是高血压重要病理基础,“木郁”是高血压发病始动因素,“土虚木郁”是高血压的关键病机。结合现代医学及分子生物学研究成果,认为肠道菌群失调及胆汁酸代谢异常分别与中医“土虚”“木郁”密切相关,并且在高血压发病过程中肠道菌群-胆汁酸轴失衡与中医“土虚木郁”相契合。从肠道菌群-胆汁酸轴角度探讨高血压“土虚木郁”的生物学内涵,对于指导中医药防治高血压有重要的理论与实践意义。

There is a bidirectional relationship between intestinal flora and bile acids,and the imbalance of intestinal flora-bile acid axis metabolism is closely related to hypertension.Based on classical TCM literature and clinical practice,this article found that“earth deficiency”is the important pathological basis of hypertension,“wood depression”is the initiating factor of hypertension,and“earth deficiency and wood depression”is the key pathogenesis of hypertension.Combined with the research results of modern medicine and molecular biology,it is considered that the imbalance of intestinal flora and abnormal bile acid metabolism are closely related to the“earth deficiency”and“wood depression”of TCM respectively,and the imbalance of intestinal flora-bile acid axis coincides with the“earth deficiency and wood depression”of TCM in the process of hypertension.It is of great theoretical and practical significance to explore the biological connotation of hypertension“earth deficiency and wood depression”from the perspective of intestinal flora-bile acid axis for guiding TCM to prevent and treat hypertension.