组织内TRIM3及FoxO1表达与原发性肝癌患者病理特征及预后间的关系分析

Correlating TRIM3 and FoxO1 in tissues with pathological features and prognosis in primary liver cancer patients

目的探讨组织内三重基序蛋白3(TRIM3)及叉头转录因子O家族1(FoxO1)表达与原发性肝癌(PHC)患者病理特征及预后间的关系。方法回顾性分析2018年1月—2019年12月南京医科大学附属淮安第一医院收治的119例PHC患者的临床资料。比较PHC患者肝癌组织与癌旁组织中的TRIM3、FoxO1表达,比较不同TRIM3及FoxO1表达PHC患者的病理特征,比较不同TRIM3及FoxO1表达PHC患者的预后。结果PHC患者肝癌组织中TRIM3、FoxO1阳性率(46.22%、42.02%)显著低于癌旁组织(75.63%、79.83%)(P<0.05)。TRIM3阳性患者肿瘤大小<5 cm、高分化、TNM分期Ⅰ~Ⅱ期的占比显著高于TRIM3阴性患者(P<0.05),FoxO1阳性患者肿瘤大小<5 cm、单发、TNM分期Ⅰ~Ⅱ期的占比显著高于FoxO1阴性患者(P<0.05)。肝癌组织内TRIM3阳性患者、TRIM3阴性患者3年生存率分别为61.82%、31.25%,差异有统计学意义(Log Rank=10.242,P=0.001);FoxO1阳性患者、FoxO1阴性患者3年生存率分别为60.00%、34.78%,差异有统计学意义(Log Rank=6.978,P=0.008)。结论组织内TRIM3及FoxO1表达与PHC患者病理特征及预后显著相关,可作为评估PHC患者病情及预后的重要指标。

Objective To investigate the association between the expression levels of tripartite motif-containing 3(TRIM3)and forkhead transcription factor O1(FoxO1)in tissues,and the pathological characteristics and prognostic implications in patients with primary hepatic carcinoma(PHC).Methods Clinical data from 119 patients with PHC treated at Huaian First Hospital Affiliated to Nanjing Medical University from January 2018 to December 2019 were retrospectively analyzed.The study aimed to compare the expression levels of TRIM3 and FoxO1 in liver cancer tissues and adjacent non-tumorous tissues of these patients.Additionally,The pathological characteristics and prognostic outcomes in patients exhibiting varing expression levels of TRIM3 and FoxO1in their PHC tissues were compared.Results In PHC patients,the expression rates of TRIM3 and FoxO1 in liver cancer tissues(46.22%,42.02%respectively)were significantly lower compared to adjacent non-tumorous tissues(75.63%,79.83%respectively)(P<0.05).Patients with positive TRIM3 expression demonstrated a significantly higher incidence of tumors smaller than 5cm,high differentiation and TNM stagesⅠ-Ⅱcompared to those with negative TRIM3 expression(P<0.05).Similarly,FoxO1 positive patients showed a significantly higher frequency of tumors smaller than 5 cm,single tumors,and TNM stagesⅠ-Ⅱcompared to FoxO1 negative patients(P<0.05).The 3-year survival rates for patients with positive TRIM3 expression(61.82%)were notably higher than those with negative expression(31.25%),with a statistically significant difference(Log Rank=10.242,P=0.001).Likewise,the 3-year survival rates were 60.00%in FoxO1-positive patients and 34.78%in FoxO1-negative patients,making a significant difference(Log Rank=6.978,P=0.008).Conclusion The expression levels of TRIM3 and FoxO1 in tissues demonstrate a substantial association with both the pathological attributes and the prognostic outlook of PHC patients,indicating their potential as vital prognostic biomarkers for evaluating patint status and predicting clinical outcomes in PHC.