四川省某三甲医院产科分娩新生儿早期肠道菌群分析

Early Colonization of Intestinal Flora of Neonates in a Grade-A Tertiary Hospital in Sichuan Province

目的分析新生儿早期肠道菌群定植情况。方法2022年7月1日至7月31日,对我院产科分娩的新生儿,于<24 h、24~72 h及≥72 h三个时间段,分别采集粪便,及时送检验科微生物培养、分离鉴定及药敏试验。结果三个时间段新生儿肠道定植细菌检出阳性率分别为23.44%、63.11%、73.77%,随着时间的推移不断升高;分层分析发现,剖宫产新生儿更易定植G+菌,而顺产新生儿更易定植G-菌;同时有2株耐碳青霉烯类肺炎克雷伯杆菌定植。结论新生儿分娩时,应做好消毒隔离措施,母亲应在分娩前后合理使用抗菌药物,预防新生儿多重耐药菌的感染。

Objective To analyze the early colonization of intestinal flora of neonates.Methods Fecal samples during July 1 to July 312022 were collected at<24 hours,24~72 hours and≥72 hours respectively,and sent to the laboratory in time for microbial culture,isolation and identification and drug susceptibility test.Results The positive rates of intestinal colonized bacteria were 23.44%,63.11%and 73.77%respectively,which increased with neonates growing.Stratified analysis showed that G+bacteria was more likely to colonize in C-section newborns,while G-bacteria was more likely to colonize vaginal newborns.Two carbapenem-resistant Klebsiella pneumoniae strains were isolated.Conclusion During the delivery of newborns,disinfection and isolation measures should be taken,and mothers should rationally use antibacterial drugs before and after delivery to prevent the infection of multi-drug-resistant bacteria in newborns.