化疗药物导致的周围神经病变中西医结合防治专家共识

Expert consensus on the prevention and treatment of chemotherapy-induced peripheral neuropathy by integrated Chinese and Western medicine

化疗药物导致的周围神经病变(CIPN)是常见的化疗不良反应之一。CIPN增加了肿瘤患者的痛苦,降低了生活质量,部分患者不得不因此而减少化疗药物剂量甚至停止化疗,影响肿瘤的治疗。该专家共识是在文献综述的基础上结合专家投票针对CIPN的定义、临床特征、发病机制、危险因素、诊断与临床评估、中医认识与辨证、预防、治疗、宣教与管理展开论述和分级推荐。希望借此提高临床医生对CIPN的了解和重视,规范地干预CIPN,改善患者预后。

Chemotherapy-induced peripheral neuropathy(CIPN)is one of the common adverse reactions of chemotherapy.CIPN increases the suffering of tumor patients and reduces the quality of life.Therefore,some patients have to reduce the dose of chemotherapy drugs or even stop chemotherapy,which affects the treatment of tumors.This expert consensus discusses and recommends the definition,clinical features,pathogenesis,risk factors,diagnosis and clinical evaluation,TCM understanding and syndrome differentiation,prevention,treatment,education,and management of CIPN based on the literature review and expert voting.It is hoped that this consensus will improve clinicians’understanding and attention to CIPN,standardize the management of CIPN,and improve patient prognosis.