血管力学生物学2023年度研究进展

Research Progress on Vascular Mechanobiology in 2023

心血管系统是一个以心脏为中心、血管为网络的力学系统,力学因素在调控心血管系统生理状态或病理进程中起到直接且关键的作用。冠心病、高血压和脑卒中等多种心血管疾病都有着相似的病理学基础,即由于血管功能失衡及损伤修复异常引起的血管重建。因此,研究力学因素如何产生生物学效应而导致血管重建,阐明心血管力学信号转导通路和力学调控途径,对于深入了解心血管活动和疾病发生的本质及其防治有重要意义。本文以力学刺激(环境)因素和关键力学响应分子为线索,总结2023年度血管力学生物学的最新研究进展。研究结果为进一步探讨力学因素在心血管疾病发病机制中的作用,寻找心血管疾病诊断的标志物和潜在靶标等提供了新思路。

The cardiovascular system is a mechanical system with the heart as the center and blood vessels as the network.Mechanical forces play a direct and key role in regulating the physiological state and pathological process of the cardiovascular system.Cardiovascular diseases such as coronary heart disease,hypertension and stroke have similar pathological basis,that is,vascular remodeling caused by vascular dysfunction and abnormal damage.Therefore,investigating how mechanical forces produce biological effects that lead to vascular remodeling,and elucidating cardiovascular mechanical signal transduction pathways and mechanical regulation pathways are of great research significance for in-depth understanding of the nature of cardiovascular disease occurrence.In this review,different mechanical forces and key mechanical response molecules are used as clues,and the latest research progress of vascular mechanobiology in 2023 is summarized.These results provide new ideas for further exploring the role of mechanical factors in the pathogenesis of cardiovascular diseases,and providing markers and potential targets for early diagnosis of the disease.