中青年体检人群非酒精性脂肪性肝病的检出情况及危险因素的多重对应分析

Multiple correspondence analysis of the detection and risk factors of non-alcoholic fatty liver disease in middle-aged and young adult population undergoing physical examination

目的分析中青年体检人群非酒精性脂肪性肝病(NAFLD)的检出情况及其危险因素的多重对应关系。方法本研究为横断面研究,选取2021年1至12月在河南省中医院健康管理中心进行体检的18~59岁的中青年人群,共15423例,收集健康体检相关资料,包括基本资料(年龄、性别、既往史、吸烟饮酒情况等),体格检查,血脂、血糖等实验室指标,腹部超声结果。采用χ^(2)检验对不同特征的体检人群非酒精性脂肪性肝病的患病情况进行比较,采用多重对应分析对相关影响因素进行统计学分析。结果本次研究共检出非酒精性脂肪性肝病5859例,检出率为37.99%。NAFLD的检出率随着年龄(χ^(2)=828.841,P<0.001)和体重指数(BMI)(χ^(2)=1889.809,P<0.001)的增加逐渐升高。分别患有高血压、糖尿病、高总胆固醇血症、高甘油三酯血症、低高密度脂蛋白胆固醇血症、高低密度脂蛋白胆固醇血症、高尿酸血症的体检者NAFLD的检出率均高于未患疾病者NAFLD的检出率(χ^(2)值分别为1223.673、364.808、444.074、2436.765、1323.736、591.478、943.069,均P<0.001)。多重对应分析显示,NAFLD与高血压、高甘油三酯血症、糖尿病、高尿酸血症、超重、肥胖、45~49岁年龄组关系密切。男性、女性的对应分析图显示NAFLD与高血压、高甘油三酯血症、高尿酸血症、超重、肥胖均有关联,在男性中,NAFLD与35~49岁年龄段关系密切,在女性中,NAFLD与45~49岁年龄组,糖尿病关系密切。结论中青年人群非酒精性脂肪性肝病的检出率较高。男性、超重肥胖、患有高血压、糖尿病、高尿酸血症、血脂异常的体检者更易患有非酒精性脂肪性肝病。

ObjectiveTo analyze the detection of non-alcoholic fatty liver disease(NAFLD)and the multiple corresponding relationships of its risk factors in a middle-aged and young adult population undergoing health check-ups.MethodsThis study was a cross-sectional study conducted on 15423 individuals aged between 18 and 59 who underwent health check-ups at the Health Management Center of Henan Provincial Hospital of Traditional Chinese Medicine from January to December 2021.Relevant health examination data was collected,including basic information(age,gender,past medical history,smoking and alcohol consumption),physical examination,laboratory indicators such as blood lipids and blood glucose,and abdominal ultrasound results.The chi-square test was used to compare the prevalence of NAFLD among different characteristics of the population,and multiple correspondence analysis was employed for statistical analysis of related influencing factors.ResultsA total of 5859 cases of NAFLD were detected in this study,with a detection rate of 37.99%.The detection rate of NAFLD gradually increased with age(χ^(2)=828.841,P<0.001)and body mass index(BMI)(χ^(2)=1889.809,P<0.001).The detection rates of NAFLD were higher in individuals with hypertension,diabetes,hypercholesterolemia,hypertriglyceridemia,low high-density lipoprotein cholesterolemia,high low-density lipoprotein cholesterolemia,and hyperuricemia compared to those without these conditions(χ^(2) value was 1223.673,364.808,444.074,2436.765,1323.736,591.478,and 943.069,respectively,all P<0.001).Multiple correspondence analysis revealed that NAFLD was closely related to hypertension,hypertriglyceridemia,diabetes,hyperuricemia,overweight,obesity,and the age group of 45-49 years.Correspondence analysis graphs for males and females showed associations between NAFLD and hypertension,hypertriglyceridemia,hyperuricemia,overweight,and obesity.In males,NAFLD was closely related to the age group of 35-49 years,while in females,it was closely associated with the age group of 45-49 years and diabetes.ConclusionsThe detection rate of non-alcoholic fatty liver disease is relatively high in middle-aged and young adult populations.Males,those who are overweight or obese,and individuals with hypertension,diabetes,hyperuricemia,or abnormal blood lipids are more susceptible to non-alcoholic fatty liver disease.