酮咯酸氨丁三醇注射液与曲马多注射液治疗急性肾绞痛的疗效对比

Comparison of the Efficacy of Ketorolac Tromethamine Injection and Tramadol Injection in the Treatment of Acute Renal Colic

目的探讨酮咯酸氨丁三醇注射液与曲马多注射液在急性肾绞痛患者中的应用效果。方法方便选取2022年1—12月厦门医学院附属第二医院收治的106例急性肾绞痛患者,按随机数表法划分为两组,各53例。参照组应用曲马多注射液治疗,研究组采取酮咯酸氨丁三醇注射液治疗。比较两组干预前后的血清学指标、疼痛缓解有效率、短期复发率情况。结果研究组干预后肿瘤坏死因子-α、白细胞介素-6、5-羟色胺、P物质均低于参照组,差异有统计学意义(P<0.01);研究组疼痛缓解总有效率为96.23%高于参照组的84.91%,差异有统计学意义(χ^(2)=3.975,P<0.05);研究组总复发率为5.66%,低于参照组18.86%,差异有统计学意义(χ^(2)=4.296,P<0.05)。结论与曲马多注射液相比,酮咯酸氨丁三醇注射液的应用,在减轻急性肾绞痛病人疼痛程度方面优势更为明显。曲马多注射液的短期复发率比酮咯酸氨丁三醇注射液高。

Objective To explore the application effect of ketorolac tromethamine injection and tramadol injection in patients with acute renal colic.Methods A total of 106 patients with acute renal colic admitted to the Second Affiliated Hospital of Xiamen Medical College from January to December 2022 were conveniently selected and divided into two groups according to the random number table method,with 53 cases in each group.The reference group was treated with tramadol injection,and the study group was treated with ketorolac tromethamine injection.The serological indexes,effective rate of pain relief and short-term recurrence rate were compared between the two groups before and after intervention.Results After intervention,the levels of tumor necrosis factor-α,interleukin-6,5-hydroxytryptamine and substance P in the study group were lower than those in the reference group,and the differences were statistically significant(P<0.01).The total effective rate of pain relief in the study group was 96.23%,which was higher than 84.91%in the reference group,and the difference was statistically significant(χ^(2)=3.975,P<0.05).The total recurrence rate of the study group was 5.66%,which was lower than 18.86%of the reference group,and the difference was statistically significant(χ^(2)=4.296,P<0.05).Conclusion Compared with tramadol injection,the application of ketorolac tromethamine injection has more obvious advantages in reducing the pain level of patients with acute renal colic.The short-term relapse rate of tramadol injection was higher than that of ketorolac tromethamine injection.