tau蛋白和磷酸化tau蛋白对神经系统疾病的影响

Effects of Tau Protein and Phosphorylated Tau Protein on Neurological Diseases

tau蛋白是一种神经元微管相关蛋白,参与轴突微管组装的调节。其磷酸化水平的增高与多种神经退行性疾病息息相关,如阿尔茨海默病、帕金森病、额颞叶痴呆、亨廷顿病,等。有研究表明其与脑血管病的发生发展密不可分。而昼夜节律作为维持机体日常生命活动以及体内稳态的重要调节器,受昼夜节律因子的调节,其紊乱可诱发神经退行性疾病相关致病蛋白的积累和相关致病激素的异常分泌,从而加剧疾病的进展。文中主要围绕磷酸化tau蛋白和昼夜节律对神经系统疾病的影响进行论述。

Tau is a neuronal microtubule-associated protein(MAP)that is involved in the regulation of axonal microtubule assembly.Its increased phosphorylation level is closely associated with several CNS degenerative diseases,such as Alzheimer's disease(AD),Parkinson's disease(PD),and frontotemporal dementia.Recent researches have also shown that it is inseparable from the development of cerebrovascular diseases.As an important regulator of daily life activities and homeostasis,circadian rhythms are regulated by circadian rhythm factors,and their dysregulation can lead to the accumulation of pathogenic proteins associated with neurodegenerative diseases,induce abnormal secretion of pathogenic hormones,and exacerbate the pathogenesis of diseases.This review focused on the effects of phosphorylated tau and circadian rhythms on neurological diseases.