多学科综合治疗时代射频消融在肝癌中的临床应用进展

Progress in clinical application of radiofrequency ablation in liver cancer in the era of multidisciplinary comprehensive treatment

多学科综合治疗是当前肝癌最佳医疗模式,联合局部和全身治疗,可延长患者生存期,提高生活质量。以射频消融为代表的局部热消融治疗具有精准微创、操作简便、疗效确切等优点,在肝细胞癌治疗的临床应用中日益广泛。射频消融作为一种精准微创的局部热消融治疗手段,与手术、介入治疗、化疗和靶向治疗等全身治疗相结合,可增加疗效并减少并发症的发生。本文综述了射频消融在肝癌治疗中的临床应用进展,探讨了多学科综合治疗时代射频消融在肝癌中的联合治疗方案。对于晚期肝细胞癌患者,射频消融联合化疗、靶向治疗和免疫治疗在治疗中显示出良好的效果,未来有望为晚期肝细胞癌患者带来更多获益。

Multidisciplinary comprehensive treatment is the best medical model for liver cancer at present,and combined local and systemic treatment can prolong the survival period and improve the quality of life of patients.Local thermal ablation therapy represented by radiofrequency ablation has the advantages of precision and minimally invasive,easy operation,and precise efficacy,and has been increasingly widely used in the clinical application of hepatocellular carcinoma treatment.Radiofrequency ablation,as a precise and minimally invasive local thermal ablation therapy,can increase the efficacy,reduce the occurrence of complications of patients by combining with systemic therapies,such as surgery,interventional therapy,chemotherapy and targeted therapy.In this paper,the clinical application progress of radiofrequency ablation in hepatocellular carcinoma treatment is reviewed,and the combined therapeutic program of radiofrequency ablation in hepatocellular carcinoma in the era of multidisciplinary comprehensive treatment is discussed.For patients with advanced hepatocellular carcinoma,radiofrequency ablation combined with chemotherapy,targeted therapy and immunotherapy has shown good effects in the treatment,which is expected to bring more benefits to patients with advanced hepatocellular carcinoma in the future.