泛素特异性蛋白酶11在中枢神经系统疾病中的作用研究进展

Recent advance in role of ubiquitin-specific protease 11 in central nervous system diseases

泛素特异性蛋白酶11(USP11)是泛素特异性蛋白酶(USPs)家族成员之一,通过介导底物的去泛素化过程,抑制靶蛋白的泛素-蛋白酶体降解,进而参与细胞周期进程、DNA损伤修复、细胞死亡、自噬、信号传导、免疫炎症反应及大脑皮层发育等多种病理生理过程的调节。研究表明,USP11在中枢神经系统(CNS)疾病的发生发展进程中具有重要作用。本文围绕USP11的结构、功能及其在CNS疾病中的作用机制研究进展进行综述,以期为靶向USP11治疗相关疾病提供新的思路。

Ubiquitin-specific protease 11(USP11)is a family member of deubiquitylases(DUBs).It mediates substrates de-ubiquitination to inhibit their ubiquitin-proteasome degradation and participates in cell cycle process,DNA damage repair,cell death,autophagy,signal transduction,immune inflammatory response,cerebral cortex development,and other physiological processes.Studies show that USP11 also plays an important role in central nervous system diseases.This article starts with the structure and functions of USP11 to systematically review the mechanism of USP11 in central nervous system diseases and provide new ideas for USP11 as a therapeutic target.