铜稳态与铜死亡在中枢神经系统疾病中的研究进展

Recent advance in role of copper homeostasis and copper death in central nervous system diseases

作为生物体内的必需微量元素,铜积极参与各系统正常生理过程并被维持在低水平,以实现铜稳态。铜稳态一旦被打破将诱导细胞死亡,这种新的细胞死亡形式被称为铜死亡。近年来,铜死亡越来越被认为是介导中枢神经系统(CNS)疾病发病和进展的重要因素,故本文围绕铜死亡在CNS疾病中的致病机制以及相应治疗策略进行综述,以期加深研究人员对其的了解。

As an essential trace element in living organisms,copper is actively involved in normal physiological processes in various systems and is maintained at low level to achieve copper homeostasis.Copper homeostasis,once being disrupted,would induce cell death,and this new form of cell death is known as copper death.In recent years,copper death has been increasingly recognized as an important factor mediating the onset and progression of central nervous system(CNS)diseases.Therefore,we review the pathogenic mechanism of copper death in CNS diseases,as well as its therapeutic strategies so as to deepen the understanding of researchers.