摘要
肠道微生物群是人类肠道内的重要组成部分,它们与人类的健康状况和疾病发生密切相关。阿尔茨海默病(AD)是一种神经退行性疾病,其潜在发病机制至今尚未得到全面阐明。近年来,有研究表明,AD患者和健康人之间肠道微生物组成存在显著差异。肠道微生物群组成的综合性变化可能通过肠-脑轴在AD的发生和进展中发挥作用。然而,这种相互联系的确切机制尚未得到充分的了解。本综述将深入探讨肠道微生物群通过肠-脑轴的调控从而影响AD的相关机制。
Gut microbiome is an important part of the human gut,which is closely related to human health and disease.Alzheimer's disease(AD)is a kind of neurodegenerative diseases,and its underlying pathogenesis has not been fully elucidated.In recent years,studies have shown obvious differences in gut microbiome composition between AD patients and healthy subjects.Comprehensive changes in gut microbiota composition may play a role in AD progression through the gut-brain axis.However,the mechanism of this interlinkage is not yet fully understood.In this review,we explore the mechanism of gut microbiota's influence in AD through gut-brain axis regulation.
作者
梁钧毅
刘斌
董晓红
蔡文辉
张宁
张红
Liang Junyi;Liu Bin;Dong Xiaohong;Cai Wenhui;Zhang Ning;Zhang Hong(Basic Medical College,Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China;Jiamusi College,Heilongjiang University of Chinese Medicine,Jiamusi 154007,China;Research Institute of Traditional Chinese Medicine,Heilongjiang University of Chinese Medicine,Harbin 150040,China;Department of Laboratory,Jiamusi Central Hospital,Jiamusi 154002,China)
出处
《中华神经医学杂志》
CAS
CSCD
北大核心
2023年第12期1287-1292,共6页
Chinese Journal of Neuromedicine
基金
黑龙江省自然科学基金(LH2023H073)。
