脑梗死治疗中的新视角:热休克蛋白的作用

New Perspectives in Cerebral Infarction Therapy:The Role of Heat Shock Proteins

脑梗死是脑组织血液供应障碍引发的一类疾病,会导致患者出现不同程度的神经功能缺损、认知功能障碍等,降低患者的生活质量。热休克蛋白(heat shock proteins,HSPs)可作为缺血相关的应激蛋白在脑组织缺血后被诱导激活,在脑损伤中起到重要作用。近年来,越来越多的研究指出HSPs与脑梗死有着密切的关联,靶向特定的HSP可缓解缺血性脑损伤,极大改善预后。因此,本文对与脑梗死相关的HSPs的最新文献进行概述,为后续靶向HSPs相关药物的研发及临床转化提供理论依据,为脑梗死提供新的治疗思路。

Cerebral infarction is a type of disease caused by blood supply disorders in brain tissue,leading to varying degrees of neurological deficits and cognitive dysfunction in patients,reducing their quality of life.Heat shock proteins(HSPs)can be induced and activated after cerebral ischemia as stress proteins related to ischemia,playing an important role in brain damage.In recent years,more and more studies have pointed out that HSPs are closely associated with cerebral infarction,and targeting specific HSPs can alleviate ischemic brain damage and greatly improve prognosis.Therefore,this review article provides an overview of the latest literature on the relevant HSPs involved in cerebral infarction,providing a theoretical basis for the subsequent development and clinical transformation of drugs targeting HSPs,offering new treatment ideas for cerebral infarction.