微小RNA工程化外泌体在糖尿病创面中的作用研究进展

Research advances on the role of microRNA engineered exosomes in diabetic wounds

糖尿病创面是糖尿病患者常见的并发症之一,治疗较为困难。目前,糖尿病创面的治疗方法包括清创、功能性敷料覆盖、负压治疗、骨水泥填充、皮肤移植等。微小RNA(miRNA)工程化外泌体具有减轻炎症、刺激血管生成、促进胶原沉积和再上皮化等功能,在糖尿病创面修复中展现出巨大潜力,相关研究正在积极开展。该文对糖尿病创面的病理生理特征、miRNA与外泌体的特性、外泌体负载miRNA的工程化方法和miRNA工程化外泌体促进糖尿病创面愈合的机制进行综述,以期为miRNA工程化外泌体在糖尿病创面中的临床应用提供参考依据。

Diabetic wounds are a common complication in patients with diabetes,which is difficult to treat.Current treatment methods for diabetic wounds include debridement,functional dressing coverage,negative pressure therapy,bone cement filling,and skin grafting,etc.MicroRNA(miRNA)engineered exosomes have shown promising potential in diabetic wound repair due to the ability to alleviate inflammation,stimulate angiogenesis,and promote collagen deposition and re-epithelialization.Related researches are being actively carred out.This paper reviews the pathophysiological characteristics of diabetic wounds,the characteristics of miRNA and exosomes,the engineering methods for exosomes loaded with miRNA,and the mechanism of miRNA engineered exosomes in promoting healing of diabetic wounds,aiming to provide a reference basis for the future clinical application of miRNA engineered exosomes in diabetic wounds.