摘要
患者创面愈合困难是临床各科室医师均有可能遇到的难题,目前仍然没有很好的解决方案。白藜芦醇是一种天然活性物质,具有抗炎、抗氧化、抗菌及促进血管新生等作用,是潜在的促进创面愈合的药物。然而,白藜芦醇因生物利用度不高等原因,临床应用受限。该文对白藜芦醇促进创面愈合的分子机制及其在创面治疗中的给药方式进行综述,以期为该药的重新开发提供思路。
The difficulty of wound healing in patients is a difficult problem that doctors in all clinical departments may encounter,and there is still no good solution.Resveratrol is a kind of natural active substance,which has anti-inflammatory,antioxidant,antibacterial,and angiogenesis promoting effects,and is a potential drug to promote wound healing.However,the clinical application of resveratrol is limited due to its low bioavailability.In this review,the molecular mechanism of resveratrol in promoting wound healing and its administration methods in wound treatment were reviewed to provide ideas for the redevelopment of resveratrol.
作者
刘钰
杨丽萍
刘白雪
周帅
李蒙
贾晴
于希军
Liu Yu;Yang Liping;Liu Baixue;Zhou Shuai;Li Meng;Jia Qing;Yu Xijun(College of Traditional Chinese Medicine,Inner Mongolia Medical University,Hohhot 010110,China;Department of Dermatology,the Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010110,China)
出处
《中华烧伤与创面修复杂志》
CAS
CSCD
北大核心
2024年第2期196-200,共5页
Chinese Journal of Burns And Wounds
基金
内蒙古自治区自然科学基金面上项目(2021MS08027,2022MS08021)
国家自然科学基金青年科学基金项目(82205127)
内蒙古自治区卫生健康委医疗卫生科技计划项目(202201189)
内蒙古医科大学面上项目(YKD2021MS023)。
关键词
伤口愈合
药理作用分子作用机制
白藜芦醇
慢性难愈性创面
给药方式
Wound healing
Molecular mechanisms of pharmacological action
Resveratrol
Chronic refractory wounds
Administration methods
