运动康复疗法治疗肺动脉高压的研究进展

Research progress of exercise rehabilitation therapy for pulmonary arterial hypertension

肺动脉高压(pulmonary arterial hypertension,PAH)是一种典型的慢性进行性加重的心肺血管疾病,生存率较低,目前的基础治疗及靶向药物治疗可以改善PAH患者的生存质量,但远期疗效及预后不佳,研究表明,在现有治疗的基础上进行运动康复疗法可以改善心肺功能储备、增强骨骼肌力量、减轻炎症反应、改善血管及心室重塑、提高患者远期生活质量和改善心理状态。本文将对PAH患者中运动康复疗法的作用及安全性等方面研究进展进行综述。

Pulmonary arterial hypertension(PAH)is a typical chronic and progressive cardiopulmonary vascular disease with low survival rate.Current basic therapy and targeted drug therapy can improve the quality of life of PAH patients,but the long-term efficacy and prognosis are not good.Studies have shown that exercise rehabilitation therapy can improve cardiopulmonary reserve,strengthen skeletal muscle strength,reduce inflammatory response,improve vascular and ventricular remodeling,improve long-term quality of life and improve psychological state of patients.This article will review the research progress in the effect and safety of exercise rehabilitation therapy for PAH patients.