目标试验模拟研究辅助实施工具CERBOT简介与应用

Introduction and application of an auxiliary implementation tool(CERBOT)for target trial emulation study

因果推断的快速发展正在引起众多学科领域研究的“范式革命”。“目标试验模拟”被认为是一种极具前景的观察性真实世界研究框架,已经受到国内外卫生领域学者和监管部门的广泛关注。本文旨在概述目标试验模拟研究进展的基础上,介绍目标试验模拟研究在线辅助实施工具CERBOT的基本情况,并通过一项实例对其操作过程进行说明,以期帮助国内研究人员开展目标试验模拟研究,并为最终促进国内医疗领域真实世界研究质量和医疗服务水平产生积极影响。

The rapid advancement of causal inference is driving a paradigm shift across various disciplines."Target trial emulation"has emerged as an exceptionally promising framework for observational real-world studies,attracting substantial attention from medical scholars and regulatory agencies worldwide.This article aims to provide an introduction to CERBOT,an online tool that assists in implementing target trial emulation studies,while highlighting the advancements in this domain.Additionally,the article provides an illustrative example to elucidate the operational process of CERBOT.The objectives are to support domestic researchers in conducting target trial emulation studies and enhance the quality of real-world studies in the domestic medical field,as well as improve the medical service level in clinical practice.