左乙拉西坦对儿童良性癫痫伴中央颞区棘波68例脑电图影响的研究

Effects of levetiracetom on electroencephalogram in 68 cases of benign epilepsy in children with centraltemporal spines

目的 探讨左乙拉西坦(LEV)对儿童良性癫痫伴中央颞区棘波(BECTS)患儿脑电图的影响。方法 收集我院2021年10月至2022年10月门诊诊断BECTS患儿资料,根据抗癫痫发作药物,分为对照组36例和研究组32例。对照组服用奥卡西平(OXC),研究组服用左乙拉西坦(LEV)。比较2组癫痫发作控制效果、脑电图痫样放电改善情况、不良反应发生情况。组间计数资料用χ^(2)检验,等级资料行秩和检验;计量资料用x±s表示,比较用t检验。结果 研究组BECTS控制效果优于对照组(Z=2.596,P<0.05)。研究组脑电图痫样放电改善效果优于对照组(Z=2.045,P<0.05)。研究组癫痫发作控制效果和脑电图痫样放电改善效果均优于对照组(P<0.05)。结论 LEV可有效控制患儿脑电图痫样放电频率和癫痫发作频率,安全有效。

Objective To investigate the effect of levetiracetam(LEV) on electroencephalogram(EEG) in children with benign epilepsy accompanied by centrotemporal spines(BECTS).Methods From October 2021 to October 2022,children with BECTS diagnosed in outpatient department were divided into control group(36 cases)and study group(32 cases) according to antiepileptic drugs.The control group received oxcarbamazepine(OXc),and the study group received LEV.χ^(2) test was used between groups,the rank sum test for ordinal data,and expressed as x±s for quantitative data,and t test was used to compare the control effect of seizure,EEG epileptic discharge improvement,and adverse reactions of the two groups.Results The BECTS control effect of the study group was better than that of the control group(Z=2.596,P<0.05).The improvement effect of EEG epileptic discharge in the study group was better than that in the control group(Z=2.045,P<0.05).The epileptic seizure control effect and EEG epileptic discharge improvement effect of the study group were better than that of the control group(P<0.05).Conclusion LEV is safe and effective in controlling EEG epileptic discharge frequency and seizure frequency in children.