摘要
炎症性肠病(inflammatory bowel disease,IBD)主要包括克罗恩病(Crohn′s disease,CD)和溃疡性结肠炎(ulcerative colitis,UC),是一种病因和发病机制至今尚不十分明确的非特异性肠道疾病,肠纤维化是IBD的常见并发症,可同时发生在UC和CD中,也是其大多数长期并发症的基础,往往形成不可逆的脏器病理生理改变,严重影响IBD患者的预后。本文根据近年来国内外关于IBD肠纤维化发生机制的研究,对其发生过程中可能涉及到的细胞因子或分子途径作一综述。
Inflammatory bowel disease(IBD),including Crohn′s disease(CD)and ulcerative colitis(UC),is a non-specific intestinal disease with unclear etiology and pathogenesis.Intestinal fibrosis is a common complication of IBD,which can occur in both UC and CD.It is also the basis of most long-term complications,often forming irreversible organ pathophysiological changes,which seriously affect the prognosis of IBD patients.Based on the research on the pathogenesis of intestinal fibrosis in IBD at home and abroad in recent years,this paper briefly reviewed the possible cytokines or molecular pathways involved in the development of intestinal fibrosis.
作者
李相辉
侯艳红
张林
LI Xianghui;HOU Yanhong;ZHANG Lin(Graduate School of Hebei North University,Zhangjiakou 075132;Department of Gastroenterology,the Eighth Medical Center,PLA General Hospital,China)
出处
《胃肠病学和肝病学杂志》
CAS
2024年第2期201-205,共5页
Chinese Journal of Gastroenterology and Hepatology
基金
首都卫生发展科研基金项目资助(2011-5007-01)。
关键词
炎症性肠病
肠纤维化
转化生长因子Β
胰岛素样生长因子-1
白细胞介素
硫氧还蛋白5
Inflammatory bowel disease
Intestinal fibrosis
Transforming growth factor-β
Insulin-like growth factor-1
Interleukin
Thioredoxin domain-containing protein 5