炎症性肠病相关肠纤维化的分子机制研究进展

Research progress of inflammatory bowel disease related intestinal fibrosis

炎症性肠病(inflammatory bowel disease,IBD)主要包括克罗恩病(Crohn′s disease,CD)和溃疡性结肠炎(ulcerative colitis,UC),是一种病因和发病机制至今尚不十分明确的非特异性肠道疾病,肠纤维化是IBD的常见并发症,可同时发生在UC和CD中,也是其大多数长期并发症的基础,往往形成不可逆的脏器病理生理改变,严重影响IBD患者的预后。本文根据近年来国内外关于IBD肠纤维化发生机制的研究,对其发生过程中可能涉及到的细胞因子或分子途径作一综述。

Inflammatory bowel disease(IBD),including Crohn′s disease(CD)and ulcerative colitis(UC),is a non-specific intestinal disease with unclear etiology and pathogenesis.Intestinal fibrosis is a common complication of IBD,which can occur in both UC and CD.It is also the basis of most long-term complications,often forming irreversible organ pathophysiological changes,which seriously affect the prognosis of IBD patients.Based on the research on the pathogenesis of intestinal fibrosis in IBD at home and abroad in recent years,this paper briefly reviewed the possible cytokines or molecular pathways involved in the development of intestinal fibrosis.