余甘子提取物与四种中药提取物复配的促消化效果的研究

Digestion promoting effects of compounds of Phyllanthus emblica L.extract and four traditional Chinese medicine extracts

通过小鼠小肠运动、胃排空、大鼠摄食量、体重增加、食物利用率、胃蛋白酶测定等实验对比余甘子提取物分别与四种提取物(陈皮、茯苓、山楂及白术)两两复配(两两复配产品),及五种提取物复配产品的促消化效果。结果表明两两复配产品及五种提取物复配产品均能显著提高小鼠小肠推进率,并能显著提高其胃排空率;五种提取物复配产品组较空白组显著提升大鼠食物利用率(P<0.05);余甘子山楂复配产品组,余甘子茯苓复配产品组及五种提取物复配产品组相较空白组大鼠的胃蛋白酶活性都有明显提升(P<0.05);除了余甘子陈皮复配提取物外,相较空白组,其他两两复配产品组均有提升大鼠胃蛋白酶排出量的效果(P<0.05)。其作用可能与提高胃肠动力及提高胃蛋白酶活力相关,本研究为余甘子等复配提取物改善胃肠消化功能提供理论依据,并为研发提高胃肠动力的产品提供思路。

The digestion promoting effects of Phyllanthus emblica L.extract in pairs with four extracts respectively(Citri Reticulatae Pericarpium,Poria cocos,hawthorn and Atractylodes macrocephala)and compound of the five extracts above were compared with the indicators such as small intestine movement,gastric emptying,food intake,weight gain,food utilization rate,and pepsin determination in mice/rats models and experiments were carried out.The results showed that the compounds of paired extracts and five extracts compound could significantly improve the small intestine propulsion rate and gastric emptying rate in mice;The mice group fed with five extracts compound could improve the food utilization rate of rats compared to the blank group(P<0.05);The pepsin activity of the rats groups fed with Phyllanthus emblica L.hawthorn compound,Phyllanthus emblica L.poria cocos compound,and the five extracts compound were all significantly increased compared to the blank group(P<0.05);Except for the compound of Phyllanthus emblica L.and Citri Reticulatae Pericarpium extracts,compared to the blank group,the other two compounds of pairs extracts groups all showed an effect of increasing pepsin excretion in rats(P<0.05).Their effects might be related to improving gastrointestinal motility and increasing pepsin activity in rats.This study provides a theoretical basis for the improvement of gastrointestinal digestion function by extracts compounds with Phyllanthus emblica L.,and provides ideas for the development of compound products with Citri Reticulatae Pericarpium to improve gastrointestinal motility.