顺铂与45种静脉用药物在Y型输液器中的物理相容性研究

Study on Physical Compatibility of Cisplatin with 45 Intravenous Drugs in Y-type Infusion Set

目的研究顺铂与45种静脉用药物通过Y型输液器物理相容性。方法顺铂用0.9%氯化钠调配为0.12mg/mL溶液,分别与用0.9%氯化钠或5%葡萄糖调配的45种静脉用药物临床用药浓度溶液模拟通过Y型输液器混合,溶液室温(20℃~23℃)、避光保存。于0小时、0.5小时、1小时、2小时、4小时考察其外观性状、p H、浊度、丁达尔效应及不溶性微粒。结果顺铂与45种静脉用药物配伍液4小时内颜色无变化,未产生浑浊、沉淀、结晶或气体;顺铂与45种静脉用药物配伍液p H与0时比较变化<1;顺铂与盐酸胺碘酮、盐酸柔红霉素和盐酸多柔比星配伍液不溶性微粒符合要求;顺铂与盐酸胺碘酮配伍液立即产生丁达尔效应,且浊度与0时比较变化﹥0.5NTU,与其他44种静脉用药物配伍液未产生丁达尔效应,浊度与0时比较变化<0.5NTU。结论顺铂与盐酸胺碘酮配伍液物理不相容,与其他44种静脉用药物配伍液物理相容。

Objective To study the physical compatibility of cisplatin and 45 intravenous drugs in Y-site administration.Methods Cisplatin was prepared into 0.12mg/mL solution with 0.9%sodium chloride,and mixed with 45 clinical concentration solutions of intravenous drugs prepared with 0.9%sodium chloride or 5%glucose,respectively,through a Y-site administration.The solutions were stored at room temperature(20~23℃)and away from light.The appearance properties,pH,turbidity,Tyndall effect and insoluble particles were recorded at 0h,0.5h,1h,2h and 4h.Results There were no color changes of the mixed solution with cisplatin and 45 intravenous drugs were observed and no turbidity,precipitation,crystallization,and gas were produced within 4 hours.The changes in pH of the mixed solution was less than 1.The insoluble particles of the admixtures of cisplatin and amiodarone hydrochloride,daunorubicin hydrochloride and doxorubicin hydrochloride meet the requirements.The Tyndall effects were observed immediately after cisplatin was mixed with amiodarone hydrochloride,and the turbidity of the admixture of cisplatin and amiodarone increased over 0.5NTU compared with 0h.No Tyndall effects were observed in 44 other admixtures and their turbidities increased less than 0.5NTU compared with 0h.Conclusion Cisplatin was physical incompatible with amiodarone hydrochloride,and was physical compatible with other 44 intravenous drugs.