血清淀粉酶、脂肪酶及C反应蛋白联合检验在急性胰腺炎诊断中的应用价值

Application Value of Combined Detection of Serum Amylase,Lipase and C-reactive Protein in the Diagnosis of Acute Pancreatitis

目的研究血清淀粉酶、脂肪酶及C反应蛋白联合检验在急性胰腺炎诊断中的应用价值。方法选取2022年1月-12月我院诊治的54例急性胰腺炎患者作为观察组,并选取同期在我院体检健康者54例作为对照组,两组均进行血清淀粉酶、脂肪酶及C反应蛋白检验,比较对照组与观察组、不同病情急性胰腺炎患者血清淀粉酶、脂肪酶及C反应蛋白水平,并分析不同检验指标的诊断效能(灵敏度、特异度、准确率、阳性预测值、阴性预测值)。结果观察组血清淀粉酶、脂肪酶及C反应蛋白水平均高于对照组(P<0.05);重度急性胰腺炎患者血清淀粉酶、脂肪酶及C反应蛋白水平均高于轻度急性胰腺炎患者(P<0.05);血清淀粉酶+脂肪酶+C反应蛋白检测诊断灵敏度、特异度、准确率、阳性预测值、阴性预测值均高于各指标单一检测,C反应蛋白检测诊断灵敏度、特异度、准确率、阳性预测值、阴性预测值均高于血清淀粉酶、脂肪酶检测(P<0.05);而血清淀粉酶检测诊断灵敏度、特异度、准确率、阳性预测值、阴性预测值与脂肪酶检测比较,差异无统计学意义(P>0.05)。结论血清淀粉酶、脂肪酶及C反应蛋白联合检验在急性胰腺炎诊断中具有较高的诊断价值,且急性胰腺炎病情与血清淀粉酶、脂肪酶及C反应蛋白水平密切相关,值得临床予以重视。

Objective To study the application value of combined detection of serum amylase,lipase and C-reactive protein in the diagnosis of acute pancreatitis.Methods A total of 54 patients with acute pancreatitis diagnosed and treated in our hospital from January to December 2022 were selected as the observation group,and 54 healthy people who underwent physical examination in our hospital during the same period were selected as the control group.Serum amylase,lipase and C-reactive protein tests were performed in both groups.Serum amylase,lipase and C-reactive protein levels were compared between the control group and the observation group,and patients with acute pancreatitis of different conditions.The diagnostic efficacy(sensitivity,specificity,accuracy,positive predictive value,negative predictive value)of different test indicators was analyzed.Results The levels of serum amylase,lipase and C-reactive protein in the observation group were higher than those in the control group(P<0.05).The levels of serum amylase,lipase and C-reactive protein in patients with severe acute pancreatitis were higher than those in patients with mild acute pancreatitis(P<0.05).The diagnostic sensitivity,specificity,accuracy,positive predictive value and negative predictive value of serum amylase+lipase+C-reactive protein detection were higher than those of single detection of each index,the diagnostic sensitivity,specificity,accuracy,positive predictive value and negative predictive value of C-reactive protein detection were higher than those of serum amylase and lipase detection(P<0.05).There was no significant difference in diagnostic sensitivity,specificity,accuracy,positive predictive value,negative predictive value between serum amylase detection and lipase detection(P>0.05).Conclusion The combined test of serum amylase,lipase and C-reactive protein has high diagnostic value in the diagnosis of acute pancreatitis,and the condition of acute pancreatitis is closely related to the levels of serum amylase,lipase and C-reactive protein,which is worthy of clinical attention.