血浆氧化三甲胺水平与心力衰竭相关性研究进展

Research Advance in the Relationship Between Plasma Trimethylamine Oxide Level and Heart Failure

肠道菌群及其代谢产物参与各种心血管疾病的发生发展,其中与心力衰竭疾病进展的关系十分密切。该文主要讨论肠道菌群代谢物氧化三甲胺(TMAO)参与心力衰竭的病理过程以及TMAO在心力衰竭中的应用价值,介绍心力衰竭患者肠道菌群及其代谢产物的变化特点,阐明了TMAO通过介导炎症反应和相关信号通路加重心肌肥厚和心力衰竭的机制。高水平TMAO与心力衰竭患者不良结局相关,对心力衰竭的预后有较好的预测价值。通过饮食、益生菌和益生元、抗菌药物、粪便移植等途径来调节TMAO水平有望成为心力衰竭的潜在治疗手段。

Intestinal microorganisms and their metabolites are involved in the pathogenesis and progression of various cardiovascular diseases,especially in the progression of heart failure.This paper mainly discussed the gut microbial metabolites trimethylamine oxide(TMAO)participated in the pathological process of heart failure,and application value of TMAO in heart failure patients.This paper introduced the change characteristics of intestinal flora and its metabolites in heart failure patients,illuminated the TMAO-mediated inflammatory response,and the related signal pathways and mechanism of myocardial hypertrophy and heart failure.High levels of TMAO are associated with poor outcomes in patients with heart failure indicating a good predictive value for the prognosis of heart failure.Regulating TMAO levels through diet,probiotics and prebiotics,antibiotics,fecal transplantation,and other pathways is expected to be a potential treatment for heart failure.