一例分泌雄激素的卵巢颗粒细胞瘤病例报道并文献复习

Androgenic granulosa cell tumor of ovary:a case report and literature review

本文回顾1例月经稀发伴痤疮数年病例。患者显示高雄激素血症和胰岛素抵抗。初始诊断考虑多囊卵巢综合征,并予以2个月的口服药物治疗,症状无明显改善。进一步超声检查提示右侧卵巢一非均质性包块(3.2 cm×3.0 cm)。遂行腹腔镜下右侧卵巢病损切除,术后病理:卵巢性索-间质细胞肿瘤、成年型颗粒细胞瘤(弥漫型)。术后3 d睾酮水平下降至正常值,且月经在术后2个月恢复来潮。本研究针对该病例总结并文献复习,患有严重高雄激素血症和男性化的女性,建议详细评估可能分泌雄激素的肿瘤。

This article reports a case of oligomenorrhea accompanied by acne over several years.The patient presented with hyperandrogenism and insulin resistance.The initial diagnosis considered polycystic ovary syndrome(PCOS)and was treated with oral medication for 2 months,with no significant improvement.Further ultrasound examination revealed a right ovarian heterogeneous mass(3.2 cm×3.0 cm).The patient underwent laparoscopic resection of the right ovarian lesion.Postoperative pathology revealed ovarian sex cord-stromal cell tumor,adult granulosa cell tumor(diffuse type).Testosterone levels decreased to the normal 3 days after the surgery,and menstruation resumed within 2 months.This article summarizes the presented case and reviews the relevant literature.For women with severe hyperandrogenism and masculinization,it is recommended to thoroughly assess the possibility of androgen-secreting tumors.