血脂代谢异常及肿瘤标志物水平与结直肠癌肝转移关系研究

Study on the relationship between abnormal lipid metabolism or tumor marker levels and liver metastasis of colorectal cancer

目的探究血脂异常及肿瘤标志物水平与结直肠癌肝转移的关系,为结直肠癌肝转移提供更高的证据支持。方法回顾分析2019年1月至2023年2月在两家医院收治均经肠镜或手术等方式获得病理诊断的结直肠癌患者115例临床资料,其中有肝转移的24例(肝转移组),无肝转移的91例(无肝转移组)。使用卡方检验比较肝转移组与无肝转移组患者的一般临床资料和血清中的总胆固醇、总甘油三酯、高密度脂蛋白、低密度脂蛋白、癌胚抗原、糖类抗原19-9水平。Logistic回归分析结直肠癌肝转移的危险因素。结果Logistic单因素分析显示总胆固醇(OR=6.780)、癌胚抗原(OR=44.611)、糖类抗原19-9(OR=11.340)水平为肝转移的危险因素(均P<0.05),多因素分析显示总胆固醇(OR=4.166)、癌胚抗原(OR=28.393)为肝转移的危险因素(均P<0.05)。结论TC、CEA升高为结直肠癌患者发生肝转移的危险因素,可能促进结直肠癌肝转移。

Objective To investigate the correlation between abnormal lipid metabolism and tumor marker levels and liver metastasis of colorectal cancer,so as to provide robust evidence for the liver metastasis of colorectal cancer.Methods The clinical data of 115 colorectal patients admitted to Huazhong University of Science and Technology Union Shenzhen Hospital and Shenzhen University General Hospital were retrospectively analyzed from January 2019 to February 2023,including 24 patients with liver metastasis(liver metastasis group)and 91 patients without liver metastasis(non-liver metastasis group).Chi-square test was used to compare the general clinical data and serum levels of total cholesterol(TC),total triglycerides,high-density lipoprotein,low-density lipoprotein,carcinoembryonic antigen(CEA),carbohydrate antigen 19-9(CA19-9)between two groups.The Logistic regression was used to analyze the risk factors for liver metastasis in colorectal cancer.Results The Logistic regression univariate analysis showed that the levels of TC(OR=6.780),CEA(OR=44.611),and CA19-9(OR=11.340)were the risk factors for liver metastasis in colorectal cancer patients(all P<0.05).The Logistic regression multivariate analysis showed that TC(OR=4.166)and CEA(OR=28.393)were the risk factors for liver metastasis in colorectal cancer patients(all P<0.05).Conclusion The serum TC and CEA levels are the risk factors for liver metastasis in patients with colorectal cancer,and maybe promote liver metastasis of colorectal cancer.