摘要
通过黄曲霉毒素B1(aflatoxin B1,AFB1)诱导大鼠肝细胞凋亡的定量数据,从而构建AFB1诱导大鼠肝细胞凋亡率的剂量效应模型。通过拟合模型获取决定系数和进一步的数学检验表明,Gamma模型(R2=0.996 4,赤池信息量准则=37.40,贝叶斯信息准则=17.19)优于其他模型。建议选用Gamma模型作为大鼠急性暴露于AFB1后肝细胞凋亡率的最优剂量效应模型,用于AFB1风险评估框架中的危害特征描述。
This study aimed to construct a dose-response model of aflatoxin B1(AFB1)-induced apoptosis rate in rat hepatocytes by using quantitative data.The coefficients of determination(R2)and further mathematical tests showed that the 2 Gamma model(R=0.9964,Akaike information criterion=37.40,and Bayesian information criterion=17.19)was superior to other models.Hence,the Gamma model was recommended as the optimal dose-response model for apoptosis rate in rat hepatocytes after acute exposure to AFB1 for hazard characterization in the framework of AFB1 risk assessment.
作者
黄奥迪
严佳惠
张昭寰
刘海泉
赵勇
欧杰
HUANG Aodi;YAN Jiahui;ZHANG Zhaohuan;LIU Haiquan;ZHAO Yong;OU Jie(College of Food Science&Technology,Shanghai Ocean University,Shanghai 201306,China;Shanghai Engineering Research Center of Aquatic Product Processing&Preservation,Shanghai 201306,China;Laboratory of Quality&Safety Risk Assessment for Aquatic Products on Storage and Preservation(Shanghai),Ministry of Agriculture and Rural Affairs,Shanghai 201306,China)
出处
《食品科学》
EI
CAS
CSCD
北大核心
2024年第3期61-67,共7页
Food Science
基金
“十三五”国家重点研发计划重点专项(2018YFC1602205)。
