正常听力儿童的失匹配负波检查

Mismatch negativity in children with normal hearing

目的 探讨正常听力儿童的失匹配负波(MMN)的特点,同时分析不同性别、不同耳儿童MMN的差异。方法 对44例纯音测听、听性脑干反应检测正常的儿童分别进行双耳的MMN检查,其中男25例,女19例。采用经典的oddball模式,标准刺激和偏差刺激分别为1 000 Hz和2 000 Hz的短纯音测试受试者MMN,观察不同性别、不同耳儿童MMN潜伏期及波幅的特点并比较差异。结果 44例受试者的双耳均可正常引出MMN波形,男性儿童左耳MMN平均潜伏期为(170.24±32.83)ms,平均波幅为(3.40±2.04)μV;男性儿童右耳MMN平均潜伏期为(172.51±24.19)ms,平均波幅为(4.20±2.29)μV;女性儿童左耳MMN平均潜伏期为(162.13±31.40)ms,平均波幅为(4.01±2.82)μV;女性儿童右耳MMN平均潜伏期为(170.30±33.11)ms,平均波幅为(3.76±2.80)μV。所有受试者左右耳间MMN潜伏期及波幅差异无统计学意义(P>0.05);男性左右耳间MMN潜伏期差异无统计学意义(P>0.05);男性左右耳间MMN波幅差异具有统计学意义(P<0.05);女性左右耳间MMN潜伏期及波幅差异均无统计学意义(P均>0.05)。男女间MMN潜伏期及波幅差异无统计学意义(P均>0.05)。结论 正常听力的儿童双耳在频率差异的短纯音刺激下均能稳定的引出MMN波形,在儿童中性别、不同耳对MMN的潜伏期和波幅无明显影响,但不能排除性别是MMN检查中影响其规范数据的一个因素,需要扩大样本量进一步研究。

Objective To study the characteristics of mismatch negativity(MMN)in children with normal hearing,and to analyze the differences of MMN between different ears and genders in normal children.Methods A total of 44 children(25 males and 19 females)with normal pure tone audiometry and auditory brainstem response were examined by MMN in both ears.Classical oddball mode was adopted.Standard and deviated stimuli were 1000 Hz and 2000 Hz,respectively.The characteristics of MMN latency and amplitude in children of different genders and ears were recorded and compared.Results MMN waveform could be elicited from both ears in all the 44 subjects.The average latency and amplitude of MMN in left ear of male children were(170.24±32.83)ms and(3.40±2.04)μV,and those in right ear of male children were(172.51±24.19)ms and(4.20±2.29)μV.The average MMN latency and amplitude of left ear of female children were(162.13±31.40)ms and(4.01±2.82)μV,while those of right ear of female children were(170.30±33.11)ms and(3.76±2.80)μV.The differences in MMN latency and amplitude between the left and right ears of all subjects were statistically insignificant(P>0.05).There was no significant difference in MMN latency between the left and right ears of males(P>0.05),while the MMN amplitude of male left and right ears was statistically different(P<0.05).There were no significant differences in MMN latency and amplitude between left and right ears of females(P>0.05).The differences in MMN latency and amplitude between males and females were statistically insignificant(P>0.05).Conclusions MMN waveform can be stably elicited under the stimulation of short pure tone with different frequencies in children with normal hearing.Their gender and different sides of ear have no significant influence on the latency and amplitude of MMN.However,gender cannot be excluded as a factor affecting the standard data of MMN,and further study with expanded sample size is needed.