复方丹参滴丸联合氨氯地平治疗原发性高血压的疗效及对血清Hcy、β2-微球蛋白、VEGF水平的影响

The Curative Effect of Compound Salvia Miltiorrhiza Dropping Pills Combined with Amlodipine in the Treatment of PrimaryHypertension and its Effect on Serum Hcy,β2-microglobulin and VEGF levels

目的研究复方丹参滴丸以及氨氯地平联用对原发性高血压的疗效及对血清同型半胱氨酸(Hcy)、β2-微球蛋白、血管内皮细胞生长因子(VEGF)水平的影响。方法选取2020年1月—2022年12月格尔木市人民医院收治的80例原发性高血压患者作为研究对象,依据随机数表法将其分为观察组和对照组,每组40例。对照组采用氨氯地平治疗,观察组在对照组治疗基础上联用复方丹参滴丸。评估并比较两组患者的眩晕昏蒙、项背强硬、肢体麻木、胸闷胸痛症状,且检测并比较血清Hcy、β2-微球蛋白和VEGF水平。结果观察组的有效率明显高于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者的眩晕昏蒙、项背强硬、肢体麻木和胸闷胸痛症状积分比较,差异无统计学意义(P>0.05);治疗后,两组患者的眩晕昏蒙、项背强硬、肢体麻木和胸闷胸痛症状积分均明显降低(P<0.05),且观察组患者的眩晕昏蒙、项背强硬、肢体麻木和胸闷胸痛症状积分更低,差异有统计学意义(P<0.05)。治疗前,两组患者的血清Hcy、β2-微球蛋白和VEGF水平比较,差异无统计学意义(P>0.05);治疗后,两组患者的血清Hcy、β2-微球蛋白和VEGF水平均明显降低(P<0.05),且观察组患者的血清Hcy、β2-微球蛋白和VEGF水平明显低于对照组,差异有统计学意义(P<0.05)。结论复方丹参滴丸以及氨氯地平联用对原发性高血压有显著的疗效,能明显降低Hcy、β2-微球蛋白和VEGF水平。

Objective To study the effect of compound salvia miltiorrhiza dropping pills combined with amlodipine in the treatment of essential hypertension and its eff ect on serum Hcy,β2-microglobulin and VEGF levels.Methods Selected 80 essential hypertension patients admitted to Golmud People's Hospital from January 2020 to December 2022 were selected,and the random number table was divided into observation group and control group,with 40 patients in each group.The control group used amlodipine,and the observation group used compound Danshen dropping based on the control group.Evaluate the symptoms of dizziness,stiff neck and back,numbness in limbs,and chest tightness and pain in both groups,and irritability symptoms of both groups,and test for serum Hcyβ2-Microglobulin and VEGF levels.Results The effective rate of the observation group was signifi cantly higher than control group(P<0.05).Before treatment,there was no signifi cant diff erence in the symptom scores of dizziness,stiff neck and back,numbness in limbs,and chest tightness and chest pain between the two groups(P>0.05).After treatment,the symptom scores of dizziness,stiff neck and back,numbness in limbs,and chest tightness and chest pain in both groups were signifi cantly reduced(P<0.05),and the symptom scores of dizziness,stiff neck and back,numbness in limbs,and chest tightness and chest pain in the observation group were lower(P<0.05).Before treatment,there was no signifi cant diff erence in the levels of serum Hcy,β2-microglobulin and VEGF(P>0.05).After treatment,the levels of serum Hcy,β2-microglobulin and VEGF were signifi cantly reduced(P<0.05),and the levels of serum Hcy,β2-microglobulin and VEGF were signifi cantly lower than those of the control group(P<0.05).Conclusion Compound Danshen dripping pills combined with amlodipine have signifi cant eff ect on primary hypertension,and can signifi cantly reduce the levels of serum Hcy,β2-microglobulin and VEGF levels.