普罗雌烯阴道胶丸联合电刺激生物反馈疗法在盆底功能障碍患者中的应用

Application of Promestriene Vaginal Capsules Combined with Electrical Stimulation Biofeedback Therapy in Patients with Pelvic Floor Dysfunction

目的:探讨普罗雌烯阴道胶丸联合电刺激生物反馈疗法在盆底功能障碍(PFD)患者中的疗效。方法:选择无锡市第二中医医院2022年2月—2023年1月收治的100例PFD患者为研究对象,采取随机数字表法分为观察组(50例)与对照组(50例)。对照组给予电刺激生物反馈疗法,观察组给予普罗雌烯阴道胶丸联合电刺激生物反馈疗法,两组均治疗3个月。治疗前及治疗3个月后,通过生物刺激反馈仪测定两组Ⅰ、Ⅱ类肌纤维肌力、肌纤维疲劳度及盆底肌电位,通过盆底功能障碍问卷(PFDI-20)评估患者盆底功能障碍程度;记录两组不良反应。结果:治疗后,两组Ⅰ、Ⅱ类肌纤维肌力明显均优于治疗前,且观察组Ⅰ、Ⅱ类肌纤维肌力均明显优于对照组,差异均有统计学意义(P<0.05)。治疗后,两组肌纤维疲劳度、PFDI-20评分均优于治疗前,且观察组均优于对照组,差异均有统计学意义(P<0.05);两组盆底肌电位均高于治疗前,且观察组高于对照组,差异均有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:普罗雌烯阴道胶丸联合电刺激生物反馈疗法可有效提高Ⅰ、Ⅱ类肌纤维肌力、盆底肌电位,改善肌纤维疲劳度及盆底功能障碍,且不良反应发生较少。

Objective:To investigate the efficacy of Promestriene Vaginal Capsules combined with electrical stimulation biofeedback therapy in patients with pelvic floor dysfunction(PFD).Method:A total of 100 patients with PFD admitted to Wuxi No.2 Chinese Medicine Hospital from February 2022 to January 2023 were selected as research objects,and were divided into observation group(50 cases)and control group(50 cases)by random number table method.The control group was given electrical stimulation biofeedback therapy,and the observation group was given Promestriene Vaginal Capsules combined with electrical stimulation biofeedback therapy,both groups were treated for 3 months.Before and 3 months after treatment,the muscle fibers muscle strength,muscle fiber fatigue and pelvic floor muscle potential of classⅠandⅡof the two groups were measured by the pelvic floor rehabilitation treatment instrument;the pelvic floor dysfunction degree of the patients was assessed by the pelvic floor distress inventory-short form 20(PFDI-20);the adverse reactions of the two groups were recorded.Result:After treatment,the muscle fibers muscle strength of classⅠandⅡin the two groups were significantly better than those before treatment,and the muscle fibers muscle strength of classⅠandⅡin the observation group were significantly better than those in the control group,the differences were statistically significant(P<0.05).After treatment,muscle fiber fatigue and PFDI-20 score in two groups were better than those before treatment,and those in the observation group were better than those in control group,the differences were statistically significant(P<0.05);pelvic floor muscle potential in two groups were higher than those before treatment,and that in the observation group was higher than that in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:Promestriene Vaginal Capsules combined with electrical stimulation biofeedback therapy can effectively improve the muscle fibers muscle strength of classⅠandⅡ,pelvic floor muscle potential,improve muscle fiber fatigue and pelvic floor dysfunction,and less adverse reactions.