司美格鲁肽联合针刺治疗2型糖尿病合并超重或肥胖40例临床观察

Clinical Observation of 40 Patients with Type 2 Diabetes Mellitus Complicated with Overweight or Obesity Treated by Smeglutide Combined with Acupuncture

目的:观察司美格鲁肽联合针刺治疗2型糖尿病合并超重或肥胖患者的临床疗效。方法:选取2型糖尿病合并超重或肥胖患者80例为研究对象,随机将患者分为两组,即对照组(n=40)和观察组(n=40),对照组单纯采用司美格鲁肽(0.25~1 mg/周)治疗,观察组采用司美格鲁肽(0.25~1 mg/周)联合针刺(1次/天,20天为一个疗程)治疗,根据患者血糖水平适当调整司美格鲁肽剂量,共治疗3个月,观察两组治疗前后的空腹血糖(FBG)、餐后2 h血糖(2 hPBG)、糖化血红蛋白(HbA1c)、体重指数(BMI)、胰岛功能(HOMA-IR)、药物不良反应和临床疗效等指标。结果:①治疗后观察组FBG、2 hPBG、HbA1c等血糖指标均低于对照组(P<0.05)。②治疗后观察组BMI、HOMA-IR均低于对照组(P<0.05)。③对照组出现腹泻、恶心呕吐等胃肠道副作用,而观察组没有出现胃肠道方面的症状,观察组药物不良反应发生率低于对照组(P<0.05)。④观察组总有效率为95%,对照组总有效率为80%,两组疗效对比有差异(P<0.05)。结论:对于2型糖尿病合并超重或肥胖患者,司美格鲁肽联合针刺治疗可更有针对性的控制血糖,降低体重指数,改善胰岛功能,同时缓解司美格鲁肽用药后的胃肠道反应,使患者依从性更好,提高了临床疗效,应用价值较高。

Objective To observe the clinical effect of Smeglutide combined with acupuncture in the treatment of type 2 diabetes mellitus patients with overweight or obesity.Methods A total of 80 patients with type 2 diabetes mellitus complicated with overweight or obesity were selected as the study subjects.The patients were randomly divided into two groups,namely control group(n=40)and observation group(n=40).The control group was treated with Smeiglutide(0.25~1 mg/week)alone.Observation group was treated with simeclutide(0.25~1 mg/week)and acupuncture(once a day,20 days as a course of treatment),and the dose of simeclutide was appropriately adjusted according to the blood glucose level of patients,and a total of 3 months was treated.Fasting blood glucose(FBG),2 h postprandish blood glucose(2 hPBG),glycated hemoglobin(HbA1c),body mass index(BMI),islet function(HOMA-IR),adverse drug reactions and clinical efficacy of the two groups before and after treatment were observed.Results①After treatment,blood glucose indexes such as FBG,2 hPBG and HbA1c in the observation group were lower than those in the control group(P<0.05).②After treatment,BMI and HOMA-IR of observation group were lower than control group(P<0.05).③The control group showed gastrointestinal side effects such as diarrhea,nausea and vomiting,while the observation group did not show gastrointestinal symptoms.The incidence of adverse drug reactions in the observation group was lower than that in the control group(P<0.05).④The total effective rate of the observation group was 95%,and the total effective rate of the control group was 80%,and there was a difference between the two groups(P<0.05).Conclusions For overweight or obese patients with type 2 diabetes mellitus,simeclutide combined with acupuncture therapy can control blood sugar more targeted,reduce body mass index,improve pancreatic function,and alleviate gastrointestinal reactions after simeclutide administration,which makes patients comply better,improves clinical efficacy and has high application value.