体重指数、腰臀比及胰岛素抵抗与绝经后子宫内膜息肉发病的相关性分析

Correlation analysis of body mas index,waist-to-hip ratio and insulin resistance with postmenopausal sendometrial polyp

目的探究体重指数(BMI)、腰臀比(WHR)及胰岛素抵抗(IR)与绝经后子宫内膜息肉(EP)发病的相关性。方法选取2021年10月至2023年1月资阳市人民医院收治的180例怀疑为绝经后EP患者作为研究对象。根据病理检查结果将其分为EP组(n=90)和非EP组(n=90)。比较两组的BMI、WHR、IR发生情况、性激素水平,分析BMI、WHR及IR与绝经后EP发病的关系。结果EP组的BMI、腰围、臀围、WHR均高于对照组(P<0.05);EP组空腹血糖(FBG)、空腹胰岛素(FIN)、稳态模型胰岛素抵抗指数(HOMA-IR)水平及IR发生率均高于非EP组(P<0.05);两组黄体生成素(LH)、卵泡刺激素(FSH)、雌二醇(E_(2))、孕酮(P)水平比较,差异无统计学意义(P>0.05);EP患者BMI、WHR与HOMA-IR均呈正相关(P<0.05);BMI、WHR、HOMA-IR是EP发生的独立危险因素。结论BMI、WHR、HOMA-IR与绝经后EP发生均具有相关性,临床需重视肥胖、胰岛素水平过高患者,定期进行妇科检查。

Objective To explore the correlation between body mass index(BMI),waist-to-hip ratio(WHR),insulin resistance(IR)and postmenopausal endometrial polyp(EP).Methods A total of 180 patients with suspected postmenopausal EP admitted to Ziyang People′s Hospital from October 2021 to January 2023 were enrolled as the research objects.According to the results of pathological examination,they were divided into EP group(n=90)and non-EP group(n=90).BMI,WHR,IR occurrence and levels of sex hormones were compared between the two groups.The relationship between BMI,WHR,IR and the occurrence of postmenopausal EP was analyzed.Results BMI,waist circumference,hip circumference and WHR in EP group were higher than those in non-EP group(P<0.05).The fasting blood glucose(FBG),fasting insulin(FIN),homeostasis model assessment of insulin resistance(HOMA-IR)and incidence of IR in EP group were higher than those in non-EP group(P<0.05).There was no significant difference in levels of luteinizing hormone(LH),follicle stimulating hormone(FSH),estradiol(E_(2))and progesterone(P)between the two groups(P>0.05).The BMI and WHR of EP patients were positively correlated with HOMA-IR(P<0.05).BMI,WHR and HOMA-IR were independent risk factors of EP.Conclusions BMI,WHR and HOMA-IR are correlated with the occurrence of postmenopausal EP.Clinical attention should be paid to patients with obesity and high insulin,and gynecological examination should be performed regularly.