摘要
目的探究新加归肾丸联合雌二醇片/雌二醇地屈孕酮片对卵巢早衰(POF)患者卵巢功能和Kupperman评分的影响。方法选取2020年12月至2022年6月成都市妇女儿童中心医院、成都市青羊区妇幼保健计划生育服务中心、成都市龙泉驿区中医医院的90例POF患者作为研究对象,按照随机数字表法分为西药组(n=30)、中药组(n=30)和联合组(n=30)。分别给予雌二醇片/雌二醇地屈孕酮片、新加归肾丸、雌二醇片/雌二醇地屈孕酮片+新加归肾丸治疗。治疗1个疗程后,对比患者治疗前后中医证候积分、Kupperman评分、卵巢功能指标,并进行疗效对比。结果联合组总有效率为93.33%,高于西药组的60.00%、中药组的76.67%(P<0.05);治疗后,联合组患者中医证候积分、Kupperman评分、血清卵泡刺激素(FSH)、黄体生成素(LH)水平显著低于中药组和西药组(P<0.05);治疗后,联合组患者雌二醇(E2)水平、卵巢体积、窦卵泡数、子宫内膜厚度显著高于西药组和中药组(P<0.05)。结论新加归肾丸联合雌二醇片/雌二醇地屈孕酮片治疗POF效果较好,可调节激素水平,优化卵巢功能。
Objective To investigate the impacts of Xinjia Guishen Pill combined with estradiol tablets/estradiol and dydrogesterone tablets on ovarian function and Kupperman score in patients with premature ovarian failure(POF).Methods A total of 90 patients with POF from Chengdu Women′s and Children′s Central Hospital,Chengdu Qingyang District Maternal and Child Health and Family Planning Service Center,and Chengdu Longquan District Hospital of Traditional Chinese Medicine from December 2020 to June 2022 were selected as the study objects.According to random number table method,they were devided into the western medicine group(n=30),Traditional Chinese Medicine(TCM)group(n=30),and combined group(n=30),and were treated with estradiol tablets/estradiol and dydrogesterone tablets,Xinjia Guishen Pill,estradiol tablets/estradiol and dydrogesterone tablets+Xinjia Guishen Pill,respectively.After one course of treatment,the TCM syndrome score,Kupperman score and ovarian function index were compared before and after treatment,and the curative effect was compared.Results The total effective rate of the combined group was 93.33%,which was higher than 60.00%in the western medicine group and 76.67%in the TCM group(P<0.05).After treatment,the TCM syndrome score,Kupperman score,serum follicle stimulating hormone(FSH)and luteinizing hormone(LH)levels in the combined group were significantly lower than those in the TCM group and the western medicine group(P<0.05).After treatment,the estradiol(E2)level,ovarian volume,the number of antral follicles and endometrial thickness in the combined group were significantly higher than those in the western medicine group and TCM group(P<0.05).Conclusions Xinjia Guishen Pill combined with estradiol tablets/estradiol and dydrogesterone tablets is effective in the treatment of POF,which can regulate hormone levels and optimize ovarian function.
作者
李晓红
李芳
龙旭
杨卓
LI Xiaohong;LI Fang;LONG Xu;YANG Zhuo(Department of Traditional Chinese Medicine,Women′s and Children′s Hospital,School of Medicine,University of Electronic Science and Technology of China(Chengdu Women′s and lChildren′s Central Hospital),Chengdu 611731,Sichuan,China;Department of Traditional Chinese Medicine,Chengdu Longquan District Hospital of Traditional Chinese Medicine,Chengdu 610017,Sichuan,China;Department of Outpatient,Women′s and Children′s Hospital,School of Medicine,University of Electronic Science and Technology of China(Chengdu Women′s and Children′s Central Hospital),Chengdu 611731,Sichuan,China;Department of Pharmaceutical,Women′s and Children′s Hospital,School of Medicine,University of Electronic Science and Technology of China(Chengdu Women′s and Children′s Central Hospital),Chengdu 611731,Sichuan,China)
出处
《中国性科学》
2024年第2期152-156,共5页
Chinese Journal of Human Sexuality
基金
四川省中医药管理局科学技术研究专项课题(2020LC0024)。
