微波消融治疗肺肿瘤的相关预后因素分析

Analysis of prognostic factors related to microwave ablation therapy for lung tumors

目的:分析微波消融治疗肺部肿瘤患者预后的相关影响因素。方法:选取解放军第九六零医院和山东省第二人民医院2014年03月到2021年04月收治的行肺部微波消融术(microwave ablation,MWA)的肿瘤患者,重点回顾性分析微波消融患者的总生存期(overall survival,OS)、无进展生存期(progression-free-survival,PFS)及不良反应、并发症的相关影响因素。结果:54例患者入组,共消融75个病灶。单因素及多因素分析后显示:肿瘤位置:胸壁2 cm之外;气管、大血管和心脏2 cm之外的患者具有更长的PFS及OS(P均<0.05)。消融患者中40例(74.1%)患者出现了不良反应及并发症,消融的功率越大,不良反应和并发症的发生概率越高(P<0.05)。不良反应及并发症均通过相应的治疗得到缓解,没有相关的死亡病例发生。结论:肿瘤位置是微波消融治疗肺部肿瘤患者PFS和OS的独立预后因素,同时,消融功率的大小与不良反应、并发症的发生率有关。

Objective:To analyze the relevant factors affecting the prognosis of patients with lung tumors treated with microwave ablation.Methods:A retrospective analysis was conducted on the overall survival(OS),progression-free-survival(PFS),and related factors of adverse reactions and complications of tumor patients who underwent lung microwave ablation from March 2014 to April 2021 at the People's Liberation Army 960 Hospital and the Second People's Hospital of Shandong Province.Results:54 patients were enrolled and a total of 75 lesions were ablated.Single factor and multivariate analysis showed that the tumor location was:2 cm away from the chest wall.Patients who are 2 cm away from the trachea,large blood vessels,and heart have longer PFS and OS(P<0.05).Among the ablation patients,40 cases(74.1%)experienced adverse reactions and complications.The higher the ablation power,the higher the probability of adverse reactions and complications(P<0.05).Adverse reactions and complications were alleviated through corresponding treatment,and no related deaths occurred.Conclusion:Tumor location is an independent prognostic factor for PFS and OS in lung cancer patients treated with microwave ablation,and ablation power is related to the incidence of adverse reactions and complications.