癌症相关性血栓发病机制的研究进展

Advances in research on the pathogenesis of cancer - related thrombosis

伴随癌症患者人群数量的扩大与生存期的延长,静脉血栓栓塞症(venous thromboembolism,VTE)成为影响癌症患者生存质量的重要并发症。在众多的并发症中,静脉血栓栓塞症已成为引起癌症患者死亡的第二大原因。探究癌症相关性血栓的发生机制对于防治工作意义重大。由于癌症的发生发展机制复杂与血栓形成联系广泛,在近年来的研究中,癌症参与的凝血级联系统激活、炎症因子、肿瘤相关产物等诱发血栓机制的几个方面得到了较多的认可。本文就近年来血栓形成与癌症相关性机制的研究进行综合叙述。

Venous thromboembolism(VTE)becomes an important complication affecting the quality of life of cancer patients with the enlargement of the population and prolonging of survival time.Among the many complications,venous thromboembolism has become the second leading cause of cancer death.To explore the mechanism of cancer-associated thrombosis is of great significance for prevention and treatment.Due to the complex mechanism of the occurrence and development of cancer and its extensive connection with thrombosis,several aspects of thrombosis induced mechanisms,such as the activation of coagulation cascade system,inflammatory factors and tumor-related products,which are involved in cancer,have been widely recognized in recent years.This article reviews the recent studies on the mechanism of thrombosis and cancer.