CD38在肿瘤微环境中的作用及治疗实体瘤进展研究

Research on the role of CD38 in tumor microenvironment and the progress in the treatment of solid tumors

肿瘤微环境包括髓样细胞、淋巴细胞、成纤维细胞和间充质干细胞等。当微环境稳态被破坏时,各成分间相互作用导致肿瘤的发生、生长和转移。CD38是一种跨膜糖蛋白,在多种实体瘤中表达失衡,可促进形成免疫抑制微环境,从而促进肿瘤生长、抑制免疫细胞活性。因此,研究者们提出针对调控肿瘤微环境中CD38的表达以提高抗肿瘤效应的策略。肿瘤抗体靶向药物的使用推动了医学的进程,进一步了解CD38的功能和其在肿瘤发生发展中的作用机制,为CD38成为实体瘤免疫治疗的新靶点提供了依据。

Tumor microenvironment includes myeloid cells,lymphocytes,fibroblasts and mesenchymal stem cells.When the microenvironment homeostasis is disrupted,the interaction between various components leads to the occurrence,growth and metastasis of tumors.CD38,a transmembrane glycoprotein,expresses unbalanced in many solid tumors.It helps to create an immunosuppressive microenvironment,thus promoting tumor growth and inhibiting immune cell activity.Therefore,the strategy of regulating the expression of CD38 in tumor microenvironment to improve anti-tumor effect has been proposed.The use of tumor antibody targeted drugs has promoted the progress of medicine.Further research will be focus on the function of CD38 and its mechanism of action in tumorigenesis and development,providing a basis for CD38 to become a new target for immunotherapy of solid tumors.