NLRP3和白细胞介素6受体与房颤相关性研究

Correlation between NLRP3,IL-6R and atrial fibrillation

目的:讨论心房颤动(AF)病人血清中的核苷酸结合寡聚化结构域受体蛋白3(NLRP3)、白细胞介素6受体(IL-6R)的表达水平以及进行两者与左房内径(LAD)的相关性研究,并探讨NLRP3、IL-6R与AF之间的关系。方法:选择AF病人150例,分为阵发性房颤(PAF)84例,非阵发性房颤(nPAF)66例。120名同期经检查排除AF的体检者作为对照组。收集3组的临床病例资料,利用酶联免疫吸附法(ELISA)检测AF病人及无AF体检者血清中的NLRP3、IL-6R的水平,在心脏彩超室测量阵发性AF病人AF未发作时的LAD,比较3组间各指标差异。结果:PAF组及nPAF组中的NLRP3和IL-6R水平均高于对照组(P<0.05),PAF组与nPAF组之间的NLRP3及IL-6R水平差异亦有统计学意义(P<0.05)。PAF组及nPAF组中的NLRP3与IL-6R均与LAD呈正相关关系(r=0.771、r=0.674,P<0.05)。NLRP3、IL-6R、LAD和年龄是AF发生的危险因素(P<0.05)。结论:NLPR3和IL-6R是AF发生的危险因素,其可能是通过影响LAD大小起作用。

Objective:To investigate the expression levels of nucleotide binding oligomeric domain receptor protein 3(NLRP3)and interleukin 6 receptor(IL-6R)in serum of patients with atrial fibrillation,analyze their correlation with left atrial diameter(LAD),and to explore the relationship between NLRP3,IL-6R and atrial fibrillation.Methods:A total of 150 patients with atrial fibrillation enrolled were divided into paroxysmal atrial fibrillation(PAF,84 patients)and non-paroxysmal atrial fibrillation(nPAF,66 patients).A total of 120 physical examiners ruled out atrial fibrillation during the same period were selected as control group.The clinical data of the three groups were collected.The level of NLRP3 and IL-6R in serum of patients and physical examiners were detected by ELISA,and the LAD of patients with PAF before atrial fibrillation was detected by color doppler ultrasound.The differences of indicators among the three groups were compared.Results:The levels of NLRP3 and IL-6R in PAF group and nPAF group were higher than those in control group(P<0.05).There were also significant differences in NLRP3 and IL-6R levels between PAF group and nPAF group(P<0.05).NLRP3 and IL-6R in PAF group and nPAF group were positively correlated with LAD(r=0.771,r=0.674,P<0.05).NLRP3,IL-6R,LAD and age were risk factors for atrial fibrillation(P<0.05).Conclusions:NLPR3 and IL-6R are risk factors for atrial fibrillation,which may play a role by affecting the diameter of LAD.