术前血清CA125水平与子宫浆液性癌宫外转移的相关性分析

Correlation analysis between preoperative serum CA125 level and extrauterine metastasis in patients with uterine serous carcinoma

目的:探讨子宫浆液性癌病人术前血清CA125水平与子宫外转移的关系。方法:回顾性收集2015-2021年诊断为子宫浆液性癌病人的临床资料,分析术前血清CA125水平与子宫外转移的相关性。结果:病人术前血清CA125水平与输卵管、卵巢和大网膜转移显著相关(P<0.05)。且当CA125≥41.36 U/mL时病人发生肿瘤子宫外转移的可能性较高(AUC=0.797,灵敏度为70.0%,特异度为88.9%,P<0.01)。多因素分析显示,术前血清CA125≥41.36 U/mL是预测肿瘤子宫外转移的危险因素(P<0.01)。同时,宫颈间质转移也与子宫外转移显著相关(P<0.05)。CA125阳性组的3年无进展生存率高于阴性组,但差异无统计学意义(χ^(2)=0.12,P>0.05);CA125阳性组的3年总体生存率高于阴性组(χ^(2)=5.60,P<0.05)。结论:术前血清CA125≥41.36 U/mL是预测子宫浆液性癌子宫外转移的可靠指标。

Objective:To analyze the relationship between preoperative serum cancer antigen 125(CA125)levels and extrauterine metastasis in patients with uterine serous carcinoma.Methods:The clinical data of patients diagnosed with serous uterine carcinoma from January 2015 to December 2021 were retrospectively analyzed to study the correlation between preoperative serum CA125 level and extrauterine metastasis.Results:Preoperative serum CA125 levels were related to fallopian tube,ovarian and omentum metastasis(P<0.05).Patients with CA125≥41.36 U/mL were more likely to have extrauterine metastasis(AUC=0.797,sensitivity 70.0%,specificity 88.9%,P<0.01).Multivariate analysis showed that preoperative serum CA125≥41.36 U/mL was a risk factor for predicting extrauterine metastasis(P<0.01).Meanwhile,stromal invasion was also significantly associated with extrauterine metastasis(P<0.05).The 3-year progression-free survival rate was higher in the CA125-positive group than in the negative group,but the difference was not statistically significant(χ^(2)=0.12,P>0.05);the 3-year overall survival rate was higher in the CA125-positive group than in the negative group(χ^(2)=5.60,P<0.05).Conclusions:Preoperative serum CA125≥41.36 U/mL is a reliable index to predict extrauterine metastasis of uterine serous carcinoma.