地奈德乳膏联合重组牛碱性成纤维细胞生长因子治疗婴幼儿刺激性尿布皮炎的临床效果

Clinical effect of Desonide Cream combined with Recombinant Bovine Basic Fibroblast Growth Factor in the treatment of irritable diaper dermatitis in infants and young children

目的评价地奈德乳膏联合重组牛碱性成纤维细胞生长因子(rb-bFGF)治疗婴幼儿刺激性尿布皮炎的临床效果和安全性。方法选取2020年1月至2021年6月赣州市妇幼保健院皮肤科门诊收治的83例尿布皮炎患儿作为研究对象,采用随机数字表法将其分为治疗组(42例)与对照组(41例)。治疗组采用rb-bFGF凝胶涂患处,待局部干燥后外涂地奈德乳膏,对照组仅用清水洗净患处,局部干燥后外涂地奈德乳膏。分别于治疗3、7、14 d随访,比较两组的疗效、愈合时间及不良反应、复发情况。结果两组患儿治疗前的严重程度指数比较,差异无统计学意义(P>0.05)。两组的总有效率比较,差异无统计学意义(P>0.05)。治疗组的治疗效果优于对照组,差异有统计学意义(P<0.05)。治疗组的治愈时间短于对照组,差异有统计学意义(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。两组的复发率比较,差异无统计学意义(P>0.05)。结论地奈德乳膏联合rb-bFGF凝胶治疗婴幼儿刺激性尿布皮炎安全、有效,复发率低,无明显不良反应,可用于临床。

Objective To evaluate the clinical efficacy and safety of Desonide Cream in combination with Recombinant Bovine Basic Fibroblast Growth Factor(rb-bFGF)in the treatment of irritable diaper dermatitis in infants and young children.Methods A total of 83 children with diaper dermatitis admitted to the Outpatient Department of Dermatology,Ganzhou Women and Children's Health Care Hospital from January 2020 to June 2021 were selected as subjects of the study.They were divided into treatment group(42 cases)and control group(41 cases)by random number table method.Treatment group was applied rb-bFGF gel to the affected area and then applied Desonide Cream after local drying,control group was only washed with clean water and applied Desonide Cream after local drying.After 3,7 and 14 days of treatment,the curative effect,healing time,adverse reactions and recurrence of the two groups were compared.Results There was no significant difference in the severity index between the two groups before treatment(P>0.05).There was no significant difference in the total effective rate between the two groups(P>0.05).The therapeutic effect of the treatment group was better than that of the control group,and the difference was statistically significant(P<0.05).The cure time of the treatment group was shorter than that of the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).There was no significant difference in recurrence rate between the two groups(P>0.05).Conclusion Desonide Cream combined with rb-bFGF gel is safe and effective in the treatment of irritant diaper dermatitis in infants and young children,with a low recurrence rate and few adverse reactions,which is applicable for clinical application.