低分子量肝素钙联合胰岛素治疗高脂血症型急性胰腺炎的临床效果

Clinical effect of low molecular weight heparin calcium combined with insulin in the treatment of hyperlipidemia acute pancreatitis

目的分析低分子量肝素钙联合胰岛素治疗高脂血症型急性胰腺炎的临床效果。方法选取2018年6月至2023年6月山东颐养健康集团淄博医院消化内科收治的高脂血症型急性胰腺炎患者作为研究对象,按随机数字表法分为对照组(32例)与试验组(32例)。对照组给予非诺贝特降脂、生长抑素抑制胰酶分泌、补液、禁食等常规治疗措施,试验组在常规治疗基础上加用低分子量肝素钙联合胰岛素治疗,比较两组患者治疗第3、5、7天三酰甘油(TG)水平、白细胞计数(WBC)、超敏C反应蛋白(hs-CRP)水平及临床治疗效果。结果试验组患者胃肠道功能恢复时间,腹胀、腹痛等症状的消失时间,血尿淀粉酶恢复正常时间均短于对照组,差异有统计学意义(P<0.05);试验组患者住院时间短于对照组,差异有统计学意义(P<0.05)。试验组治疗第3天TG、hs-CRP、WBC水平均低于对照组,差异有统计学意义(P<0.05);试验组治疗第5天TG、hs-CRP、WBC水平均低于对照组,差异有统计学意义(P<0.05);试验组治疗第7天TG、hs-CRP、WBC水平均低于对照组,差异有统计学意义(P<0.05)。结论低分子量肝素钙联合胰岛素对高脂血症型急性胰腺炎的治疗效果显著,可应用于临床。

Objective To analyze the clinical effect of low molecular weight heparin calcium combined with insulin in the treatment of hyperlipidemic acute pancreatitis.Methods Patients with hyperlipidemic acute pancreatitis admitted to the Department of Gastroenterology of Shandong Healthcare Group Zibo Hospital from June 2018 to June 2023 were selected as the research objects,and they were divided into control group(32 cases)and experimental group(32 cases)according to random number table method.The control group was given Fenofibrate lipid-lowering,somatostatin inhibiting pancreatic enzyme secretion,fluid rehydration,fasting and other conventional treatment measures,and the experimental group was given low molecular weight heparin calcium combined with insulin therapy on the basis of conventional treatment.The levels of triglyceridemia(TG),white blood cell count(WBC),hypersensitive C-reactive protein(hs-CRP)and clinical therapeutic effect were compared between the two groups at the 3rd,5th and 7th day of treatment.Results The recovery time of gastrointestinal function,the disappearance time of abdominal distension and abdominal pain,and the recovery time of hematuric amylase in experimental group were shorter than those in control group,the differences were statistically significant(P<0.05).The hospital stay of experimental group was shorter than that of control group,and the difference was statistically significant(P<0.05).The levels of TG,hs-CRP and WBC in experimental groups were lower than those in control group on the 3rd day of treatment,and the differences were statistically significant(P<0.05).The levels of TG,hs-CRP and WBC in experimental groups were lower than those in control group on the 5th day of treatment,and the differences were statistically significant(P<0.05).The levels of TG,hs-CRP and WBC in experimental groups were lower than those in control group on the 7th day of treatment,and the differences were statistically significant(P<0.05).Conclusion Low molecular weight heparin calcium combined with insulin is effective in the treatment of hyperlipidemic acute pancreatitis and can be used in clinic.