乳腺组织定位标记夹在乳腺癌新辅助化疗中的应用效果

Application effect of breast tissue location-based marker clip in neoadjuvant chemotherapy for breast cancer

目的探讨乳腺组织定位标记夹在乳腺癌新辅助化疗中的应用效果。方法选取2020年8月至2022年8月九江市第一人民医院乳腺科收治的60例乳腺癌新辅助化疗患者作为研究对象,按照随机数字表法将患者分为对照组(30例)与试验组(30例),其中对照组在新辅助化疗后行术前导丝定位乳腺病灶,试验组则在新辅助化疗前放置乳腺组织定位标记夹,完成病灶定位后由同一治疗组医师进行手术治疗。对两组保乳手术率、保乳切缘阴性率、前哨淋巴结活检率、病理评估准确率进行比较,同时比较两组引流管留置时间、住院时间和住院费用。结果试验组保乳手术率、保乳切缘阴性率、前哨淋巴结活检率、病理评估准确率均高于对照组,差异有统计学意义(P<0.05);试验组手术时间、引流管留置时间和住院时间短于对照组,住院费用低于对照组,差异有统计学意义(P<0.05)。结论乳腺组织定位标记夹应用在乳腺癌新辅助化疗中,能精准定位乳腺原发灶及腋窝转移淋巴结,改善乳腺癌患者预后,可获得较好的社会和经济效益,在临床上值得应用和推广。

Objective To investigate the application effect of breast tissue location-based marker clip in neoadjuvant chemotherapy for breast cancer.Methods Sixty patients with neoadjuvant chemotherapy for breast cancer admitted to the Breast Department of the First People's Hospital of Jiujiang from August 2020 to August 2022 were selected as the study objects.According to the random number table method,the patients were divided into the control group(30 cases)and the experimental group(30 cases).In the control group,preoperative guide wire was performed to position breast lesions after neoadjuvant chemotherapy.In the experimental group,breast tissue localization marker clips were placed before neoadjuvant chemotherapy,and after completion of lesion localization,surgeons in the same treatment group performed surgical treatment.The rate of breast-conserving operation,the negative rate of breast-conserving incision margin,the rate of sentinel lymph node biopsy and the accuracy rate of pathological evaluation were compared between the two groups.Meanwhile,the retention time of drainage tube,the length of hospital stay and the hospitalization cost were compared between the two groups.Results The breast-preserving operation rate,breast-preserving incising margin negative rate,sentinel lymph node biopsy rate and pathological evaluation accuracy rate of experimental group were higher than those of control group,the differences were statistically significant(P<0.05).The operation time,drainage tube retention time and hospitalization time of experimental group were shorter than those of control group,and the hospitalization cost was lower than that of control group,the differences were statistically significant(P<0.05).Conclusion The application of breast tissue location marker clip in neoadjuvant chemotherapy for breast cancer can accurately locate the primary breast focus and axillary metastatic lymph nodes,improve the prognosis of breast cancer patients,and obtain good social and economic benefits,which is worthy of clinical application and promotion.