尼莫地平治疗椎基底动脉供血不足的血液流变学及脑干诱发电位观察

Effect of Nimodipine on hemorrheology and BAEP in the patients with vertebrobasilar insufficiency

目的探讨尼莫地平治疗椎基底动脉供血不足 (VBI)的作用机理。方法 5 0例VBI患者分为尼莫地平治疗组 2 5例和常规治疗组 2 5例 ,治疗前及治疗 1个月后检测血液流变学指标及脑干听觉诱发电位 (BAEP)。结果治疗前VBI患者血液粘度增高 ,表现为全血粘度高低切变值、血浆粘度及血脂增高。BAEP总异常率为 76% ,以脑干型异常为主。治疗后两组血液流变学及神经传导功能均有明显改善 (P <0 0 5 )。与常规治疗组相比 ,尼莫地平组血浆粘度水平降低更显著 (P <0 0 5 ) ,V波峰潜伏期、III V和I V峰间潜伏期明显改善 (P <0 0 5 )。结论尼莫地平可改善VBI患者血液流变学情况及脑神经传导功能。

ObjectiveTo observe the effect of Nimodipine on the hemorrheology and brainstem auditory evoked potentials (BAEP) in the patients with vertebrobasilar insufficiency (VBI) and to explore the mechanism.Methods50 cases with VBI were divided into Nimodipine group (25 cases) and routine therapy group (25 cases). The hemorrheology and BAEP were measured before the treatment and 1 month later.ResultsThe blood viscosity,including the whole blood viscosity shear value, plasma viscosity and blood fat of patients with VBI was increased. The total abnormity rate of BAEP was 76%. The main abnormity was brainstem type. The hemorrheology and the function of nerve conduction were improved distinctly ( P<0.05) after treatment. Compared with the routine therapy group, the level of plasma viscosity was decreased markedly ( P<0.05) in Nimodipine group, and peak latency of V wave, interpeak latency of III-V and I-V were also improved significantly ( P<0.05).Conclusions Nimodipine can improve the hemorrheology and the function of nerve conduction in patients with VBI.