射血分数超常的心力衰竭研究进展

Research progress on heart failure with supranormal left ventricular ejection fraction

心力衰竭是各种心血管疾病的终末阶段,因病死率和致残率高成为重大公共卫生事件。左室射血分数(LVEF)大小与心力衰竭的预后相关,并将心力衰竭分为三类,即射血分数降低型心力衰竭(HFrEF)、射血分数轻度降低型心力衰竭(HFmEF)和射血分数保留型心力衰竭(HFpEF)。近期研究指出,射血分数≥65%的心力衰竭可能因药物疗效不佳和预后不良独立于上述三种分类,被认为是一种新的心力衰竭分型,即射血分数超常型心力衰竭(HFsnEF)。本文就概念及临床特征、病理生理机制及诊断与治疗的研究现状做一综述。

Heart failure is the final stage of various heart problems and has become a major public health concern because of its high mortality and disability rate.The size of the left ventricular ejection fraction is linked to the prognosis of heart failure which includes three categories:heart failure with reduced ejection fraction,heart failure with middle ejection fraction,and heart failure with preserved ejection fraction.Recent studies suggest that heart failure with an ejection fraction≥65%may be different from above-mentioned three types,as it responds poorly to the medications and has a worse prognosis.This is considered a new kind of heart failure,known as heart failure with supranormal left ventricular ejection fraction.In this article,we will discuss the current researches on the concept,clinical features,pathophysiological mechanism,diagnosis and treatment of heart failure with supranormal left ventricular ejection fraction.