MCI老年人群血清维生素D水平与认知功能及抑郁情绪的相关性研究

Exploring the correlation between serum vitamin D levels,cognitive function,and depressive mood in elderly individuals with MCI

目的探讨轻度认知功能障碍(MCI)老年人群血清维生素D水平与认知功能及抑郁情绪的相关性,为临床干预提供理论基础。方法2023年2—8月对社区老人展开筛查,入组315例MCI受试者,采血测量维生素D水平,其中维生素D缺乏组155人和正常组160人,比较2组一般情况、简易智力状态检查量表(MMSE)、蒙特利尔认知评估量表(MoCA)、老年抑郁量表(GDS)、流调用抑郁自评量表(CES-D)评分差异。结果与正常组比较,维生素D缺乏组MMSE的即刻记忆[(9.01±1.41)分vs.(8.46±2.36)分],计算[(3.64±1.60)分vs.(3.20±1.76)分],回忆[2.00(1.00,3.00)分vs.2.00(1.00,2.00)分],复述[1.00(0.00,1.00)分vs.1.00(0.00,1.00)分],三步命令[(2.59±0.71)分vs.(2.28±0.90)分],总分[(25.10±3.05)分vs.(23.56±3.90)分],MoCA语言、回忆、总分均明显降低(P<0.05)。维生素D缺乏组CES-D总分[(13.10±4.12)分vs.(11.26±4.81)分]明显高于正常组(P<0.01)。维生素D水平与总体认知功能具有正相关关系(P<0.05),与抑郁情绪存在负相关关系(P<0.05)。结论MCI人群维生素D水平与认知功能和抑郁存在相关关系。

Objective The objective of this study is to investigate the correlation among serum vitamin D levels,cognitive function,and depressive mood in elderly individuals with mild cognitive impairment(MCI),aiming to establish a theoretical foundation for clinical intervention.Methods Between February 2023 and August 2023,a total of 315 subjects with MCI were screened from the elderly community population.Blood samples were collected to measure vitamin D levels,with 155 subjects categorized as vitamin D deficient group and 160 subjects categorized as normal group.A comparative analysis was conducted to assess the general conditions of these two groups.Additionally,scores from the mini-mental state examination(MMSE),the Montreal cognitive assessment(MoCA),the geriatric depression scale(GDS),and centre for epidemiological studies depression scale(CES-D)were compared between the two groups.Results Compared with the normal group,the vitamin D deficient group exhibited significantly lower scores in immediate memory(9.01±1.41 vs.8.46±2.36),calculation(3.64±1.60 vs.3.20±1.76),memory[2.00(1.00,3.00)vs.2.00(1.00,2.00)],repeat[1.00(0.00,1.00)vs.1.00(0.00,1.00)],and three-step command(2.59±0.71 vs.2.28±0.90)of MMSE.The total score(25.10±3.05 vs.23.56±3.90),and language score of MoCA,as well as memory and total score,were also significantly lower in the vitamin D deficient group(P<0.05).Furthermore,the total score of CES-D in the vitamin D deficient group(13.10±4.12 vs.11.26±4.81)was significantly higher(P<0.01).Correlation analysis revealed a positive association between vitamin D levels and overall cognitive function(P<0.05),while serum vitamin D levels showed a negative correlation with depressive mood(P<0.05).Conclusion Vitamin D level has been found to be associated with cognition and depression in individuals with MCI.