基于中医传承计算平台探析广西地区多囊卵巢综合征的证候特点及中医药治疗的组方规律

Syndrome characteristics of polycystic ovary syndrome and prescription rulesof Traditional Chinese Medicine therapy in Guangxi region: an explorationbased on the Traditional Chinese Medicine Inheritance Computing System

目的 基于中医传承计算平台探析广西地区多囊卵巢综合征(PCOS)的证候特点及中医药治疗的组方规律。方法 在中国知识资源总库、维普资讯中文期刊服务平台和中国学术期刊数据库中检索2013—2023年间中医药治疗PCOS的相关文献,建立中医药数据库,利用中医传承计算平台(V3.5)统计分析PCOS的证候特点及中医药物的性味、归经和功效,并进行关联规则分析和聚类分析。结果 共纳入文献51篇,得出10类证候,出现频次由高至低依次为肾虚、痰湿阻滞、血瘀、脾虚、肝郁、痰阻、气滞、湿聚、浊毒、气虚。涉及102味中药,四气以温性、平性为主,五味以甘味、苦味、辛味为主,归经以肝经、脾经、肾经为主,功效以补虚类为主,活血化瘀类次之。关联规则分析结果显示,常用药物的用药模式共6种,关联规则共4条。网络拓扑分析结果显示,中医药治疗PCOS的药物主要有当归、茯苓、菟丝子、川芎、陈皮。聚类分析结果显示,中医药治疗PCOS的核心药物组合为:(1)当归、茯苓、菟丝子、川芎、甘草;(2)苍术、茯苓、菟丝子、半夏、陈皮;(3)菟丝子、当归、茯苓、甘草、陈皮。结论 广西地区PCOS患者以肾虚、脾虚、痰湿、血瘀与肝郁证候为主,用药以补虚类为主,活血化瘀类次之,基础方剂以左归丸、四物汤、苍附导痰丸、逍遥散为主。

Objective To explore the syndrome characteristics of polycystic ovary syndrome(PCOS)and prescriptions rules of Traditional Chinese Medicine therapy in Guangxi region based on the Traditional Chinese Medicine Inheritance Computing System.Methods Literature related to Traditional Chinese Medicine for the treatment of PCOS from 2013 to 2023 was retrieved from China National Knowledge Infrastructure,VIP,and China Science Periodical Database,and a Traditional Chinese Medicine database was established.The Traditional Chinese Medicine Inheritance Computing System(V3.5)was used to statistically analyze syndrome characteristics,and property,flavor,meridians and efficacy of Traditional Chinese Medicinal materials,as well as to perform the association rule analysis and cluster analysis.Results A total of 51 literature was enrolled,obtaining 10 categories of syndromes,and the frequency from high to low was kidney deficiency,phlegm-dampness block,blood stasis,spleen deficiency,liver depression,phlegm block,qi stagnation,damp accumulation,turbid toxicity,and qi deficiency.A total of 102 flavors of Traditional Chinese Medicines were concerned,four properties of herbs were mainly warm and moderate,five flavors of herbs were mainly sweet,bitter and acrid,meridians were mainly liver meridian,spleen meridian and renal meridian,and efficacy was mainly category of reinforcing deficiency,followed by category of promoting blood circulation to remove blood stasis.The results of association rule analysis revealed that there were 6 categories of medication modes of common use drugs,and 4 association rules in total.The results of network topology indicated that drugs of Traditional Chinese Medicine for the treatment of PCOS were mainly Angelica sinensis,Poria cocos,Cuscutae semen,Chuanxiong rhizoma,Citrus reticulata.The results of cluster analysis presented that core drug combinations of Traditional Chinese Medicine for the treatment of PCOS were as follows:(1)Angelica sinensis,Poria cocos,Cuscutae semen,Chuanxiong rhizoma,and licorice,(2)Atractylodes lancea,Poria cocos,Cuscutae semen,Pinellia ternata,and Citrus reticulata,(3)Cuscutae semen,Angelica sinensis,Poria cocos,licorice,and Citrus reticulata.Conclusion PCOS patients in Guangxi region are mainly characterized by kidney deficiency,spleen deficiency,phlegm dampness,blood stasis,and liver depression.The main medications are categories of reinforcing deficiency,followed by categories of promoting blood circulation to remove blood stasis.The basic prescriptions are Zuogui Pills,Siwu Decoction,Cangfu Daotan Pills,and Xiaoyao Powder.