复发性流产患者应用阿司匹林联合泼尼松治疗的效果分析

Effect analysis of aspirin combined with prednisone in patients with recurrent spontaneous abortion

目的分析阿司匹林联合泼尼松治疗复发性流产(RSA)患者的临床效果。方法120例RSA患者,以双色球随机抽取法分为对照组与研究组,每组60例。研究组患者给予阿司匹林+泼尼松治疗,对照组患者怀孕后按血清孕酮(P)和人绒毛膜促性腺激素(HCG)值给予黄体酮治疗、常规保胎治疗。比较两组患者治疗效果、不良妊娠结局发生率以及治疗前后的凝血功能[活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)]、生殖激素[P、雌二醇(E2)、HCG]。结果研究组治疗有效率95.00%高于对照组的81.67%(P<0.05)。研究组APTT(36.56±2.46)s、PT(11.57±1.28)s均长于对照组的(34.55±1.96)、(10.17±0.95)s(P<0.05)。研究组患者P(34.79±6.93)μg/L、E2(553.81±54.02)ng/L、HCG(7023.55±530.91)IU/L均高于对照组的(23.75±5.70)μg/L、(452.82±49.63)ng/L、(4749.28±495.71)IU/L(P<0.05)。研究组不良妊娠结局发生率5.00%低于对照组的16.67%(P<0.05)。结论RSA患者应用阿司匹林+泼尼松治疗的效果确切,可进一步推广。

Objective To analyze the clinical effect of aspirin combined with prednisone in patients with recurrent spontaneous abortion(RSA).Methods 120 cases of RSA patients were divided into a control group and a study group by two-color ball random extraction method,with 60 cases in each group.The study group was given aspirin+prednisone treatment,while the control group was given progesterone treatment and routine fetal preservation treatment according to serum progesterone(P)and human chorionic gonadotropin(HCG)after pregnancy.The treatment effect,incidence of adverse pregnancy outcomes,coagulation function[activated partial thromboplastin time(APTT),prothrombin time(PT)],reproductive hormones[P,estradiol(E2),HCG]before and after treatment were compared between the two groups.Results The effective rate of the study group was 95.00%,which was higher than 81.67%of the control group(P<0.05).APTT of(36.56±2.46)s and PT of(11.57±1.28)s in the study group were longer than(34.55±1.96)and(10.17±0.95)s in the control group(P<0.05).The study group had P of(34.79±6.93)μg/L,E2 of(553.81±54.02)ng/L,and HCG of(7023.55±530.91)IU/L,which were higher than(23.75±5.70)μg/L,(452.82±49.63)ng/L,and(4749.28±495.71)IU/L in the control group(P<0.05).The incidence of adverse pregnancy outcome in the study group was 5.00%,which was lower than 16.67%in the control group(P<0.05).Conclusion The effect of aspirin+prednisone in the treatment of RSA patients is definite,and this method can be further promoted.