粪菌移植临床应用规范及前景

Clinical applicable standards and prospects of fecal microbiota transplantation

肠道菌群失调已经被证明与多个系统的疾病的发生密切相关。粪菌移植作为近年来出现的新的治疗模式,可以改善受者肠道菌群组成,并取得良好的临床效益,展现出了巨大的治疗潜力。除了被纳入复发性艰难梭菌感染的诊疗指南,粪菌移植还被应用于许多其他疾病的临床研究。多个国家和地区相继出台指南或专家共识规范粪菌移植在临床实践和研究中的应用。本文将对粪菌移植的临床应用规范和未来展望进行述评。

Intestinal microbiota dysbiosis has been demonstrated to be closely associated with the onset of various systemic diseases.Fecal microbiota transplantation(FMT),as a new treatment mode emerging in recent years,has achieved favorable clinical outcomes by improving the composition of the recipient's intestinal microbiota,thereby showing significant therapeutic potential.In FMT has been recommended by guidelines for recurrent Clostridioides difficile infection,and it also be applied to many clinical studies for other diseases.Several countries and regions have published guidelines or expert consensus to standardize the application of FMT in clinical practice and research.This review will discuss the clinical applicable standards of FMT and provide insights into future prospects.